硫代葡萄糖苷及其水解产物作为防治 SARS-CoV-2 细胞因子风暴的潜在营养保健品。
Glucosinolates and their hydrolysis products as potential nutraceuticals to combat cytokine storm in SARS-COV-2.
机构信息
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ric Scalzo Institute for Botanical Research, Southwest College of Naturopathic Medicine, Tempe, AZ, 85282, USA.
出版信息
Daru. 2022 Jun;30(1):245-252. doi: 10.1007/s40199-022-00435-x. Epub 2022 Feb 2.
INTRODUCTION
The high mortality rate in severe cases of COVID-19 is mainly due to the strong upregulation of cytokines, called a cytokine storm. Hyperinflammation and multiple organ failure comprise the main clinical features of a cytokine storm. Nrf2 is a transcription factor which regulates the expression of genes involved in immune and inflammatory processes. Furthermore, Nrf2, as a master regulator, controls the activity of NF-κB which binds to the promoter of many pro-inflammatory genes inducible of various inflammatory factors. Inhibition of Nrf2 response was recently demonstrated in biopsies from patients with COVID-19, and Nrf2 agonists inhibited SARS-CoV-2 replication across cell lines in vitro. Glucosinolates and their hydrolysis products have excellent anti-inflammatory and antioxidant effects via the Nrf2 activation pathway, reduction in the NF-κB activation, and subsequent reduced cytokines levels.
CONCLUSION
Accordingly, these compounds can be helpful in combating the cytokine storm associated with COVID-19.
简介
COVID-19 重症患者的高死亡率主要是由于细胞因子的强烈上调，即细胞因子风暴。细胞因子风暴的主要临床特征是炎症过度活跃和多器官衰竭。Nrf2 是一种转录因子，可调节参与免疫和炎症过程的基因的表达。此外，Nrf2 作为主调控因子，控制 NF-κB 的活性，NF-κB 结合到许多诱导各种炎症因子的促炎基因的启动子上。最近在 COVID-19 患者的活检中证明了 Nrf2 反应的抑制，并且 Nrf2 激动剂在体外通过 Nrf2 激活途径抑制 SARS-CoV-2 复制，减少 NF-κB 的激活，从而减少细胞因子的水平。
结论
因此，这些化合物在对抗 COVID-19 相关的细胞因子风暴方面可能会有所帮助。
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