Gu Wenbo, Zhang Jiacheng, Ren Chunling, Gao Yang, Zhang Tongfang, Long Yujia, Wei Wei, Hou Shaoying, Sun Changhao, Wang Changhong, Jiang Wenbo, Zhao Junfei
Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
Comprehensive Test Center of Chinese Academy of Inspection and Quarantine, Gao Bei Dian North Rd A3, Chao Yang District, Beijing, China.
Front Oncol. 2022 Sep 28;12:970021. doi: 10.3389/fonc.2022.970021. eCollection 2022.
The association between acrylamide (AA) and the development of cancer has been extensively discussed but the results remained controversial, especially in population studies. Large prospective epidemiological studies on the relationship of AA exposure with cancer mortality were still lacking. Therefore, we aimed to assess the association between AA biomarkers and cancer mortality in adult population from National Health and Nutrition Examination Survey (NHANES) 2003-2014. We followed 3717 participants for an average of 10.3 years. Cox regression models with multivariable adjustments were performed to determine the relationship of acrylamide hemoglobin adduct (HbAA) and glycidamide hemoglobin adduct (HbGA) with cancer mortality. Mediation analysis was conducted to demonstrate the mediated role of low-grade inflammation score (INFLA-score) in this correlation. Compared with the lowest quintile, participants with the highest quintile of HbAA, HbGA and HbAA+HbGA had increased cancer mortality risk, and the hazard ratios(HRs) were 2.07 (95%CI:1.04-4.14) for HbAA, 2.39 (95%CI:1.29-4.43) for HbGA and 2.48 (95%CI:1.28-4.80) for HbAA+HbGA, respectively. And there was a considerable non-linearity association between HbAA and cancer mortality ( = 0.0139). We further found that increased INFLA-score significantly mediated 71.67% in the effect of HbGA exposure on increased cancer mortality risk. This study demonstrates that hemoglobin biomarkers of AA are positively associated with cancer mortality in adult American population and INFLA-score plays a mediated role in this process. Our findings can raise public awareness of environmental and dietary exposure to acrylamide and remind people to refrain from smoking or having acrylamide-rich foods.
丙烯酰胺（AA）与癌症发生之间的关联已被广泛讨论，但结果仍存在争议，尤其是在人群研究中。关于AA暴露与癌症死亡率关系的大型前瞻性流行病学研究仍然缺乏。因此，我们旨在评估2003 - 2014年美国国家健康与营养检查调查（NHANES）成年人群中AA生物标志物与癌症死亡率之间的关联。我们对3717名参与者进行了平均10.3年的随访。采用多变量调整的Cox回归模型来确定丙烯酰胺血红蛋白加合物（HbAA）和环氧丙酰胺血红蛋白加合物（HbGA）与癌症死亡率之间的关系。进行中介分析以证明低级别炎症评分（INFLA评分）在此相关性中的中介作用。与最低五分位数相比，HbAA、HbGA和HbAA + HbGA最高五分位数的参与者癌症死亡风险增加，HbAA的风险比（HRs）为2.07（95%CI：1.04 - 4.14），HbGA为2.39（95%CI：1.29 - 4.43），HbAA + HbGA为2.48（95%CI：1.28 - 4.80）。并且HbAA与癌症死亡率之间存在显著的非线性关联（P = 0.0139）。我们进一步发现，INFLA评分增加在HbGA暴露对癌症死亡风险增加的影响中显著介导了71.67%。本研究表明，AA的血红蛋白生物标志物与美国成年人群的癌症死亡率呈正相关，且INFLA评分在此过程中起中介作用。我们的研究结果可以提高公众对丙烯酰胺环境和饮食暴露的认识，并提醒人们戒烟或避免食用富含丙烯酰胺的食物。
