Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Department of Food and Life Science, School of Life and Environmental Science, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.
Nutrients. 2020 Aug 12;12(8):2417. doi: 10.3390/nu12082417.
Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-µg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
丙烯酰胺是一种在高碳水化合物含量的热处理食品中形成的可能人类致癌物。本研究旨在使用日本公共卫生中心前瞻性研究的数据评估膳食丙烯酰胺摄入量与肺癌之间的关联。我们的研究纳入了 85303 名完成食物频率问卷的参与者。使用 Cox 比例风险回归模型，在调整混杂因素后评估危险比和 95%置信区间（CI）。在平均 14.3 年和 15.4 年的随访期后，男性和女性分别确定了 1187 例和 485 例肺癌病例。丙烯酰胺摄入量每增加 10µg/天的多变量调整后的危险比为 1.01（95%CI，0.99-1.02）男性和 0.98（95%CI，0.95-1.02）女性。与丙烯酰胺摄入量最低四分位数相比，最高四分位数的危险比为 1.13（95%CI，0.95-1.33；趋势=0.12）男性和 1.03（95%CI，0.78-1.36；趋势=0.86）女性在多变量调整模型中。此外，在肺癌组织学亚型的分层分析中也未观察到显著关联。本研究表明，在日本人群中，膳食丙烯酰胺摄入量与肺癌风险增加无关。
