Pandey G N, Goel I, Davis J M
Clin Pharmacol Ther. 1979 Jul;26(1):96-102. doi: 10.1002/cpt197926196.
We studied the effects of neuroleptic and antidepressant drugs on Li+ uptake in human red cells to examine the reported neurotoxicity reported for lithium-neuroleptic combination treatment and its relationship to altered tissue Li+ levels. All the phenothiazines increased Li+ influx in red cells and steady-state Li+ distribution ratio in vitro. This effect was not observed with other drugs studied. It is suggested that increased levels of Li+ in the tissue caused by phenothiazines may be related to neurotoxic effects observed during Li+ -phenothiazine therapy.
我们研究了抗精神病药物和抗抑郁药物对人红细胞摄取锂离子的影响，以检验锂盐与抗精神病药物联合治疗时所报道的神经毒性，及其与组织中锂离子水平改变的关系。所有的吩噻嗪类药物均增加了红细胞中锂离子的流入及体外稳态锂离子分布比率。在所研究的其他药物中未观察到这种效应。提示吩噻嗪类药物所引起的组织中锂离子水平升高可能与锂盐 - 吩噻嗪治疗期间观察到的神经毒性作用有关。
