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在潮湿环境中，通过氧化石墨烯超薄薄膜与阳离子表面活性剂相结合，实现抗菌涂层的持久效果。

Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment.

机构信息

Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.

Division of Periodontology and Endodontology, Department of Oral Rehabilitation School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, Hokkaido, 061-0293, Japan.

出版信息

Sci Rep. 2022 Oct 18;12(1):16721. doi: 10.1038/s41598-022-21205-4.

DOI:10.1038/s41598-022-21205-4
PMID:36257962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9579177/
Abstract

Antimicrobial surfactants contained in mouthrinse have excellent efficacy, but are not retained on the tooth surface (are rinsed away) due to their low water resistance and thus do not exhibit sustained antibacterial activity. We have developed a new coating method using graphene oxide (GO) that retains the surfactant on the tooth surface even after rinsing with water, thus providing a sustained antibacterial effect. Ultra-thin films of GO and an antimicrobial agent were prepared by (1) applying GO to the substrate surface, drying, and thoroughly rinsing with water to remove excess GO to form an ultrathin film (almost a monolayer, transparent) on the substrate surface, then (2) applying antimicrobial cationic surface active agents (CSAAs) on the GO film to form a composite coating film (GO/CSAA). GO/CSAA formation was verified by scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and ζ-potential and contact angle measurements. GO/CSAA was effective at inhibiting the growth of oral pathogens for up to 7 days of storage in water, and antibacterial activity was recovered by reapplication of the CSAA. Antibacterial GO/CSAA films were also formed on a tooth substrate. The results suggest that GO/CSAA coatings are effective in preventing oral infections.

摘要

漱口水中含有的抗菌表面活性剂具有优异的功效，但由于其耐水性低，会被水冲洗掉，因此无法在牙齿表面保留并表现出持续的抗菌活性。我们开发了一种使用氧化石墨烯 (GO) 的新涂层方法，即使在用水冲洗后，表面活性剂也能保留在牙齿表面，从而提供持续的抗菌效果。通过以下两种方法制备了 GO 和抗菌剂的超薄膜：(1) 将 GO 施加到基底表面，干燥并用大量水彻底冲洗以去除多余的 GO，从而在基底表面形成超薄膜（几乎为单层，透明），然后(2) 将抗菌阳离子表面活性剂 (CSAA) 施加到 GO 膜上以形成复合涂层膜 (GO/CSAA)。通过扫描电子显微镜、拉曼光谱、X 射线光电子能谱以及 ζ 电位和接触角测量来验证 GO/CSAA 的形成。GO/CSAA 在水中储存长达 7 天时能有效抑制口腔病原体的生长，并且通过重新施加 CSAA 可以恢复其抗菌活性。GO/CSAA 抗菌薄膜也在牙齿基底上形成。结果表明，GO/CSAA 涂层在预防口腔感染方面非常有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/5f898cbfa394/41598_2022_21205_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/3ca784775a11/41598_2022_21205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/706f4ab196dc/41598_2022_21205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/1e48363fa68d/41598_2022_21205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/9b36c285a9ad/41598_2022_21205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/b1ad4163f779/41598_2022_21205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/2a4d1c79b16c/41598_2022_21205_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/67305751a799/41598_2022_21205_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/5f898cbfa394/41598_2022_21205_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/3ca784775a11/41598_2022_21205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/706f4ab196dc/41598_2022_21205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/1e48363fa68d/41598_2022_21205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/9b36c285a9ad/41598_2022_21205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/b1ad4163f779/41598_2022_21205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/2a4d1c79b16c/41598_2022_21205_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/67305751a799/41598_2022_21205_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac8/9579177/5f898cbfa394/41598_2022_21205_Fig8_HTML.jpg

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