染色质相分离的计算机模拟。
Computer simulations of chromatin phase separation.
机构信息
Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany.
出版信息
Biophys J. 2022 Nov 15;121(22):4244-4246. doi: 10.1016/j.bpj.2022.10.007. Epub 2022 Oct 19.
Abstract
Several simulation studies have recently appeared in Biophysical Journal that investigate the formation of biomolecular condensates in the nucleus. These structures explain a large variety of biological phenomena, from epigenetic inheritance, to enhancer-promoter interactions, to the spatial organization of the entire cell nucleus.
摘要
最近，《生物物理期刊》上发表了几项模拟研究，旨在探究核内生物分子凝聚体的形成。这些结构解释了大量的生物学现象，从表观遗传遗传到增强子-启动子相互作用，再到整个细胞核的空间组织。
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Impact of chromosomal organization on epigenetic drift and domain stability revealed by physics-based simulations.基于物理模拟揭示的染色体组织对表观遗传漂移和结构域稳定性的影响。
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The interplay of chromatin phase separation and lamina interactions in nuclear organization.染色质相分离和核纤层相互作用在核组织中的相互作用。
Biophys J. 2021 Nov 16;120(22):5005-5017. doi: 10.1016/j.bpj.2021.10.012. Epub 2021 Oct 13.
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