Jafarinia Morteza, Farrokhi Majid Reza, Ganjalikhani Hakemi Mazdak, Cho William C
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Neurosurgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hum Cell. 2023 Jan;36(1):62-75. doi: 10.1007/s13577-022-00813-2. Epub 2022 Oct 19.
Mesenchymal stem/stromal cells (MSCs) are multipotent cells with immunomodulatory effects that have been attempted as a possible treatment for neurologic disorders. Since currently available drugs for neurologic disorders are limited, special attention has been paid to MSCs. With the ability to differentiate into neural cells, it has been shown that MSCs exert their effects in a paracrine manner by producing extracellular vesicles (EVs). Extracellular vesicles are small vesicles with a size of 30-1000 nm that are released by cells, such as MSCs, T cells, B cells, etc. EVs contain various molecules, including proteins, lipids, mRNAs, and microRNAs (miRNAs). In recent years, the administration of EVs in models of neurological disorders has been shown to improve neurological dysfunctions. miRNAs from MSC-EVs as one of the important mediators which regulate various genes and reduce neuropathological change have been identified in different neurological disorders. Here, we review the effects of EVs miRNAs from MSCs on different neurological disorders and their potential applications.
间充质干/基质细胞（MSCs）是具有免疫调节作用的多能细胞，已被尝试作为治疗神经系统疾病的一种可能方法。由于目前可用于治疗神经系统疾病的药物有限，MSCs受到了特别关注。MSCs具有分化为神经细胞的能力，研究表明其通过产生细胞外囊泡（EVs）以旁分泌方式发挥作用。细胞外囊泡是由MSCs、T细胞、B细胞等细胞释放的大小为30 - 1000纳米的小囊泡。EVs包含各种分子，包括蛋白质、脂质、mRNA和微小RNA（miRNAs）。近年来，在神经系统疾病模型中给予EVs已显示可改善神经功能障碍。在不同的神经系统疾病中，已鉴定出MSCs来源的EVs中的miRNAs是调节各种基因并减少神经病理变化的重要介质之一。在此，我们综述了MSCs来源的EVs中的miRNAs对不同神经系统疾病的影响及其潜在应用。
