Human colorectal disorders in the digestive tract are recognized by reference colonoscopy. The current system recognizes cancer through a three-stage system that utilizes two sets of colonoscopy data. However, identifying polyps by visualization has not been addressed. The proposed system is a five-stage system called ColoRectalCADx, which provides three publicly accessible datasets as input data for cancer detection. The three main datasets are CVC Clinic DB, Kvasir2, and Hyper Kvasir. After the image preprocessing stages, system experiments were performed with the seven prominent convolutional neural networks (CNNs) (end-to-end) and nine fusion CNN models to extract the spatial features. Afterwards, the end-to-end CNN and fusion features are executed. These features are derived from Discrete Wavelet Transform (DWT) and Vector Support Machine (SVM) classification, that was used to retrieve time and spatial frequency features. Experimentally, the results were obtained for five stages. For each of the three datasets, from stage 1 to stage 3, end-to-end CNN, DenseNet-201 obtained the best testing accuracy (98%, 87%, 84%), ((98%, 97%), (87%, 87%), (84%, 84%)), ((99.03%, 99%), (88.45%, 88%), (83.61%, 84%)). For each of the three datasets, from stage 2, CNN DaRD-22 fusion obtained the optimal test accuracy ((93%, 97%) (82%, 84%), (69%, 57%)). And for stage 4, ADaRDEV-22 fusion achieved the best test accuracy ((95.73%, 94%), (81.20%, 81%), (72.56%, 58%)). For the input image segmentation datasets CVC Clinc-Seg, KvasirSeg, and Hyper Kvasir, malignant polyps were identified with the UNet CNN model. Here, the loss score datasets (CVC clinic DB was 0.7842, Kvasir2 was 0.6977, and Hyper Kvasir was 0.6910) were obtained.