Ma Ji-Xian, Tian Si-Wen, Liu Qiu-Ping
Vitreoretinal Department, Affiliated Eye Hospital of Nanchang University, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Int J Ophthalmol. 2022 Oct 18;15(10):1699-1706. doi: 10.18240/ijo.2022.10.20. eCollection 2022.
To evaluate the effectiveness of peripheral defocus spectacle lenses (PDLs) in myopia control.
Literature retrieval on PubMed, Cochrane Library, Embase, and Web of Science databases, and the search time limit was from the establishment of each database to December 29, 2021 were conducted. Change of spherical equivalent refraction (SER) and axial change (AL) were extracted from the literatures that met the inclusion criteria, and RevMan5.3 software was used for Meta-analysis.
A total of 4 randomized controlled trials (RCTs) were included in this Meta-analysis, involving 770 myopic children. The results showed that PDLs could delay the progression of myopia in children with myopia compared with single vision spectacle lenses (SVLs; WMD=0.21 D, 95%CI: 0.01, 0.41, =0.04). However, there was no significant difference in controlling the growth of axial length (AL) in myopic children (WMD=-0.10 mm, 95%CI: -0.21, 0.01, =0.07). The results of the effectiveness of myopia control between the two spectacle lenses showed that PDLs were more effective in controlling the progression of myopia (OR=5.73, 95%CI: 2.58, 12.70, <0.001) and delaying the growth of AL (OR=44.25, 95%CI: 8.84, 221.58, <0.001) than SVLs, and the differences were statistically significant.
PDLs can control the progression of myopia compared with SVLs, but cannot delay the growth of AL, and the effectiveness of PDLs in myopia control better than SVLs.
评估周边离焦眼镜片（PDL）在控制近视方面的有效性。
在PubMed、Cochrane图书馆、Embase和科学网数据库进行文献检索，检索时间范围为各数据库建库至2021年12月29日。从符合纳入标准的文献中提取等效球镜度（SER）变化和眼轴变化（AL），并使用RevMan5.3软件进行Meta分析。
本Meta分析共纳入4项随机对照试验（RCT），涉及770名近视儿童。结果显示，与单光眼镜片（SVL）相比，PDL可延缓近视儿童近视进展（加权均数差[WMD]=0.21 D，95%置信区间[CI]：0.01，0.41，P=0.04）。然而，在控制近视儿童眼轴长度（AL）增长方面无显著差异（WMD=-0.10 mm，95%CI：-0.21，0.01，P=0.07）。两种眼镜片在控制近视有效性方面的结果表明，与SVL相比，PDL在控制近视进展（比值比[OR]=5.73，95%CI：2.58，12.70，P<0.001）和延缓AL增长（OR=44.25，95%CI：8.84，221.58，P<0.001）方面更有效，差异具有统计学意义。
与SVL相比，PDL可控制近视进展，但不能延缓AL增长，且PDL在控制近视方面比SVL更有效。
