Petrosyan Astgik, Montali Filippo, Peloso Andrea, Citro Antonio, Byers Lori N, La Pointe Catherine, Suleiman Mara, Marchetti Alice, Mcneill Eoin P, Speer Allison L, Ng Wai Hoe, Ren Xi, Bussolati Benedetta, Perin Laura, Di Nardo Paolo, Cardinale Vincenzo, Duisit Jerome, Monetti Alexandra Rose, Savino John Richard, Asthana Amish, Orlando Giuseppe
GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Department of General Surgery, di Vaio Hospital, Fidenza, Italy.
Front Bioeng Biotechnol. 2022 Sep 28;10:1015628. doi: 10.3389/fbioe.2022.1015628. eCollection 2022.
Regenerative medicine (RM) is changing how we think and practice transplant medicine. In regenerative medicine, the aim is to develop and employ methods to regenerate, restore or replace damaged/diseased tissues or organs. Regenerative medicine investigates using tools such as novel technologies or techniques, extracellular vesicles, cell-based therapies, and tissue-engineered constructs to design effective patient-specific treatments. This review illustrates current advancements in regenerative medicine that may pertain to transplant medicine. We highlight progress made and various tools designed and employed specifically for each tissue or organ, such as the kidney, heart, liver, lung, vasculature, gastrointestinal tract, and pancreas. By combing both fields of transplant and regenerative medicine, we can harbor a successful collaboration that would be beneficial and efficacious for the repair and design of engineered whole organs for transplantations.
再生医学正在改变我们对移植医学的思考方式和实践方式。在再生医学中，目标是开发和应用能够再生、修复或替换受损/患病组织或器官的方法。再生医学利用诸如新技术或工艺、细胞外囊泡、基于细胞的疗法以及组织工程构建体等工具进行研究，以设计针对患者的有效治疗方案。本综述阐述了再生医学中可能与移植医学相关的当前进展。我们重点介绍了所取得的进展以及专门为每个组织或器官（如肾脏、心脏、肝脏、肺、血管系统、胃肠道和胰腺）设计和应用的各种工具。通过将移植医学和再生医学这两个领域结合起来，我们可以实现成功的合作，这将有利于并有效地修复和设计用于移植的工程化全器官。
