Hematology and Blood Transfusion Division, Clinical and Experimental Oncology Department, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), R. Dr. Diogo de Farias, 824, Vila Clementino, São Paulo, SP, 04037-002, Brazil.
Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, Av. Prof. Lineu Prestes, 1730-Butantã, São Paulo, 05508-000, Brazil.
Inflamm Res. 2022 Dec;71(12):1403-1416. doi: 10.1007/s00011-022-01646-3. Epub 2022 Oct 20.
The inflammasome is a cytosolic multi-protein complex responsible for the proteolytic maturation of pro-inflammatory cytokines IL-1ß and IL-18 and of gasdermin-D, which mediates membrane pore formation and the cytokines release, or eventually a lytic cell death known as pyroptosis. Inflammation has long been accepted as a key component of hematologic conditions, either oncological or benign diseases.
This study aims to review the current knowledge about the contribution of inflammasome in hematologic diseases. We attempted to depict the participation of specific inflammasome receptors, and the possible cell-specific consequence of complex activation, as well as the use of anti-inflammasome therapies.
We performed a keyword-based search in public databases (Pubmed.gov, ClinicalTrials.gov.).
Different blood cells variably express inflammasome components. Considering the immunosuppression associated with both the disease and the treatment of some hematologic diseases, and a microenvironment that allows neoplastic cell proliferation, inflammasomes could be a link between innate immunity and disease progression, as well as an interesting therapeutic target.
炎症小体是一种细胞溶质多蛋白复合物，负责促炎细胞因子 IL-1β 和 IL-18 以及 gasdermin-D 的蛋白水解成熟，后者介导膜孔形成和细胞因子释放，或最终导致称为细胞焦亡的裂解性细胞死亡。炎症一直被认为是血液病的一个关键组成部分，无论是肿瘤性疾病还是良性疾病。
本研究旨在综述炎症小体在血液病中的作用。我们试图描述特定炎症小体受体的参与，以及复合物激活的可能细胞特异性后果，以及使用抗炎症小体疗法。
我们在公共数据库（Pubmed.gov、ClinicalTrials.gov.）中进行了基于关键词的搜索。
不同的血细胞不同程度地表达炎症小体成分。考虑到某些血液病的疾病和治疗相关的免疫抑制，以及允许肿瘤细胞增殖的微环境，炎症小体可能是先天免疫和疾病进展之间的联系，也是一个有趣的治疗靶点。
