Trehan Sandeep, Chaudhary Neena, Bhasarkar Ashwin
Department of Otorhinolaryngology and Head and Neck Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):3359-3366. doi: 10.1007/s12070-022-03213-y. Epub 2022 Oct 15.
Coronavirus disease 2019 (COVID-19) may be associated with a wide range of bacterial and fungal co-infections. Acute invasive fungal sinusitis is an aggressive infection affecting immunocompromised patients and high mortality rate. Here, in this case series, we have reviewed three cases of COVID-19 associated rhino-orbital invasive fungal disease. Patients with COVID-19 associated pneumonia with diabetes mellitus are at an increased risk of developing invasive pulmonary fungal infections probably due to their reduced immunological competence. Concurrent glucocorticoid therapy probably heightens the risk of mucormycosis. Physicians should be aware of and should have high index of suspicion of possible fungal infection in post COVID-19 patients. Aggressive management both medical and surgical, is required to improve outcomes of secondary invasive fungal infections in patients with COVID-19 infection.
The online version contains supplementary material available at 10.1007/s12070-022-03213-y.
2019冠状病毒病（COVID-19）可能与多种细菌和真菌合并感染有关。急性侵袭性真菌性鼻窦炎是一种侵袭性感染，影响免疫功能低下的患者，死亡率高。在此病例系列中，我们回顾了3例COVID-19相关的鼻眶侵袭性真菌病病例。患有COVID-19相关肺炎且患有糖尿病的患者发生侵袭性肺部真菌感染的风险增加，可能是由于其免疫能力下降。同时使用糖皮质激素治疗可能会增加毛霉菌病的风险。医生应意识到并高度怀疑COVID-19康复患者可能存在真菌感染。需要积极的药物和手术治疗，以改善COVID-19感染患者继发性侵袭性真菌感染的治疗效果。
在线版本包含可在10.1007/s12070-022-03213-y获取的补充材料。
