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脊髓灰质炎重返美国:一项流行病学警报。

Polio returns to the USA: An epidemiological alert.

作者信息

Rai Anushree, Uwishema Olivier, Uweis Lama, El Saleh Rayyan, Arab Sara, Abbass Mortada, Wellington Jack, Musabirema Felix, Adanur Irem, Patrick Onyeaka Chinyere Vivian

机构信息

Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.

Chhattisgarh Institute of Medical Sciences, Bilaspur, Chhattisgarh, India.

出版信息

Ann Med Surg (Lond). 2022 Sep 6;82:104563. doi: 10.1016/j.amsu.2022.104563. eCollection 2022 Oct.

Abstract

On July 21, 2022, the USA witnessed the first case of poliomyelitis after 3 decades of its eradication. Poliomyelitis is a crippling disease that results from infection with any one of the three related poliovirus types (referred to as types P1, P2, and P3), members of the enterovirus (picornavirus) family. The New York State Department of Health confirmed that a case of paralytic poliomyelitis was reported from a 20-year-old Hungarian traveller residing in Rockland County. The detected viral sequence has been found to have vaccine-derived poliovirus type 2 (VDPV2) suggesting an origin from the live attenuated oral polio vaccine (OPV). Since immunisation remains the only preventable measure, this article explores suggestions from the Centers for Disease Control and Prevention on reliable Inactivated (killed) polio vaccination in high-risk patients along with early case detection and treatment. In light of the above-mentioned findings, this research further details future recommendations like cessation of the OPV, encouragement of inactivated polio vaccine (IPV) in vaccination schedules, sensitive epidemiological surveillance system and appropriate training for healthcare providers. The affected countries have been further advised to have effective outbreak response strategy plans in place so that they can respond and stay prepared for such outbreaks in the future.

摘要

2022年7月21日,美国在宣布根除脊髓灰质炎30年后出现了首例脊髓灰质炎病例。脊髓灰质炎是一种致残性疾病,由肠道病毒(微小核糖核酸病毒)家族的三种相关脊髓灰质炎病毒类型(称为P1型、P2型和P3型)中的任何一种感染引起。纽约州卫生部证实,一名居住在罗克兰县的20岁匈牙利旅行者报告了一例麻痹性脊髓灰质炎病例。检测到的病毒序列被发现是疫苗衍生2型脊髓灰质炎病毒(VDPV2),表明其起源于减毒活口服脊髓灰质炎疫苗(OPV)。由于免疫接种仍然是唯一的预防措施,本文探讨了疾病控制与预防中心针对高危患者可靠的灭活脊髓灰质炎疫苗接种以及早期病例检测与治疗提出的建议。鉴于上述发现,本研究进一步详细阐述了未来的建议,如停止使用OPV、在疫苗接种计划中鼓励使用灭活脊髓灰质炎疫苗(IPV)、建立敏感的流行病学监测系统以及为医疗保健提供者提供适当培训。受影响国家还被进一步建议制定有效的疫情应对战略计划,以便能够对这类疫情做出反应并为未来做好准备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce0d/9577438/3390ff28e518/gr1.jpg

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