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抗生素治疗对生存及易感性的评估。 (原文中“to”后面似乎缺失了内容)

Assessment of antibiotic treatment on survival and susceptibility to .

作者信息

Dos Santos Najara Akira Costa, Magi Felipe Neves, Andrade Alice Oliveira, Bastos Alessandra da Silva, Pereira Soraya Dos Santos, Medeiros Jansen Fernandes, Araujo Maisa da Silva

机构信息

Postgraduate Program in Experimental Biology, Federal University of Rondonia/Fiocruz Rondonia, Porto Velho, Brazil.

Platform of Production and Infection of Malaria Vectors (PIVEM), Laboratory of Entomology, Fiocruz Rondonia, Porto Velho, Brazil.

出版信息

Front Microbiol. 2022 Oct 5;13:971083. doi: 10.3389/fmicb.2022.971083. eCollection 2022.

Abstract

Antibiotic treatment has been used to enhance anopheline susceptibility to infection, because bacterial microbiota play a fundamental role in modulating the vector competence of mosquitoes that transmit parasites. However, few studies have examined the impact of antibiotic treatments on sporogonic development in neotropical anopheline mosquitoes. Herein, we assessed the impact of antibiotic treatment on development and survival in , the main vector of malaria in the Amazon region. Female mosquitoes were treated continuously with antibiotics to impact the gut bacterial load and then tested for prevalence, infection intensity, and survival in comparison with untreated mosquitoes. Antibiotic-fed mosquitoes had not dramatic impact on development previously observed in . However, antibiotic treatment increases mosquito survival, which is known to increase vectorial capacity. These findings raise questions about the effect of antibiotics on development and survival in .

摘要

抗生素治疗已被用于提高按蚊对感染的易感性,因为细菌微生物群在调节传播寄生虫的蚊子的媒介能力方面起着重要作用。然而,很少有研究考察抗生素治疗对新热带地区按蚊孢子生殖发育的影响。在此,我们评估了抗生素治疗对亚马逊地区疟疾主要传播媒介——[按蚊名称未给出]的发育和生存的影响。用抗生素持续处理雌蚊以影响其肠道细菌载量,然后与未处理的蚊子相比,检测其感染率、感染强度和生存率。喂食抗生素的蚊子对[按蚊名称未给出]先前观察到的发育没有显著影响。然而,抗生素治疗可提高蚊子的生存率,而这已知会增加媒介能力。这些发现引发了关于抗生素对[按蚊名称未给出]发育和生存影响的疑问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f889/9583876/bb9ca2ffef22/fmicb-13-971083-g001.jpg

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