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病例报告：疟原虫裂殖子黑色素在疟疾病媒按蚊中肠和唾液腺的形成。

Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi.

机构信息

Plataforma de Produção e Infecção de Vetores da Malária- PIVEM, Laboratório de Entomologia, Fiocruz Rondônia, Porto Velho, Rondônia, Brazil.

Instituto Nacional de Epidemiologia da Amazônia Ocidental (INCT-EpiAMO), Porto Velho, RO, Brazil.

出版信息

Am J Trop Med Hyg. 2024 Feb 13;110(3):444-447. doi: 10.4269/ajtmh.23-0349. Print 2024 Mar 6.

DOI:10.4269/ajtmh.23-0349
PMID:38350139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919193/
Abstract

Anopheles darlingi is the primary malaria vector in the Amazon region and is highly susceptible to both Plasmodium vivax and Plasmodium falciparum parasites. Although anopheline mosquitoes may develop melanotic encapsulation in response to Plasmodium parasites, there is no record of An. darlingi exhibiting a melanization response to P. vivax, the main malaria parasite in the Americas. Here, we report the occurrence of P. vivax sporozoite melanization in An. darlingi mosquitoes.

摘要

致倦库蚊是亚马逊地区的主要疟疾传播媒介，对间日疟原虫和恶性疟原虫都高度敏感。尽管按蚊可能会对疟原虫产生黑化包囊反应，但尚无关于安蚊对美洲主要疟原虫间日疟原虫表现出黑化反应的记录。在这里，我们报告了在致倦库蚊中出现间日疟原虫孢子黑素化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b2/10919193/c6adf6c5ef8d/ajtmh.23-0349f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b2/10919193/9e41750e86de/ajtmh.23-0349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b2/10919193/c6adf6c5ef8d/ajtmh.23-0349f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b2/10919193/9e41750e86de/ajtmh.23-0349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b2/10919193/c6adf6c5ef8d/ajtmh.23-0349f2.jpg

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本文引用的文献

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Sci Rep. 2023 Oct 24;13(1):18207. doi: 10.1038/s41598-023-44556-y.
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Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification.疟原虫通过谷氨酰胺环化酶介导的翻译后蛋白质修饰来逃避蚊子的免疫。
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Malaria oocysts require circumsporozoite protein to evade mosquito immunity.
对不完全特化寄生虫的抗性与耐受性：马利筋蝴蝶及其原生动物寄生虫
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疟原虫卵囊需要裂殖子表面蛋白来逃避蚊子的免疫。
Nat Commun. 2022 Jun 9;13(1):3208. doi: 10.1038/s41467-022-30988-z.
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Evaluation of sustainable susceptibility to Plasmodium vivax infection among colonized Anopheles darlingi and Anopheles deaneorum.评估定居民间按蚊和德氏按蚊对间日疟原虫感染的可持续易感性。
Malar J. 2022 Jun 3;21(1):163. doi: 10.1186/s12936-022-04204-8.
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evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor.通过与疟原虫 47 （Pf47 ）中肠受体相互作用，疟原虫逃避按蚊的免疫。
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Brazil's first free-mating laboratory colony of Nyssorhynchus darlingi.巴西首个达林按蚊自由交配实验室种群。
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