Division of Pulmonary & Critical Care Medicine, Department of Medicine, Intermountain Medical Center, 5121 South Cottonwood Street, Salt Lake City, UT 84107, USA; Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Pharmacy Services, Intermountain Healthcare, 4393 S Riverboat Road, Taylorsville, UT 84123, USA.
Med Clin North Am. 2022 Nov;106(6):949-960. doi: 10.1016/j.mcna.2022.08.002. Epub 2022 Aug 10.
In late 2019, SARS-CoV-2 caused the greatest global health crisis in a century, impacting all aspects of society. As the COVID-19 pandemic evolved throughout 2020 and 2021, multiple variants emerged, contributing to multiple surges in cases of COVID-19 worldwide. In 2021, highly effective vaccines became available, although the pandemic continues into 2022. There has been tremendous expansion of basic, translational, and clinical knowledge about SARS-CoV-2 and COVID-19 since the pandemic's onset. Treatment options have been rapidly explored, attempting to repurpose preexisting medications in tandem with development and evaluation of novel agents. Care of the seriously ill patient is examined.
2019 年末，SARS-CoV-2 引发了一个世纪以来最大的全球卫生危机，影响了社会的各个方面。随着 2020 年和 2021 年 COVID-19 疫情的发展，出现了多种变异株，导致全球 COVID-19 病例多次激增。2021 年，出现了高效的疫苗，尽管疫情仍持续到 2022 年。自疫情爆发以来，人们对 SARS-CoV-2 和 COVID-19 的基础、转化和临床知识有了巨大的扩展。治疗方案也在迅速探索，试图与新型药物的开发和评估一起重新利用现有药物。对重症患者的治疗进行了探讨。
