Linkola J, Ylikahri R, Fyhquist F, Wallenius M
Acta Physiol Scand. 1978 Oct;104(2):180-7. doi: 10.1111/j.1748-1716.1978.tb06265.x.
The effect of ethanol intoxication and hangover on immunoreactive plasma arginine vasopressin (AVP) concentration was studied in 7 healthy supine men in controlled clinical conditions. In 6 subjects plasma AVP increased above control values at the time of maximal blood ethanol concentration. The highest AVP values were observed in the subjects having nausea and vomiting and the worst hangover symptoms. During hangover plasma AVP values were higher than the controls and the response of plasma AVP to upright posture was exaggerated. The dissociation of plasma AVP concentration and ethanol diuresis suggested that the suppression of AVP release is not the sole determinant of ethanol diuresis. The study may indicate that the toxic effects of ethanol and the severity of hangover symptoms are associated with the state of hydration and individual sensitivity of AVP triggering mechanisms.
在可控的临床条件下，研究了7名健康仰卧男性乙醇中毒和宿醉对免疫反应性血浆精氨酸加压素（AVP）浓度的影响。在6名受试者中，血浆AVP在血乙醇浓度最高时升高至高于对照值。在出现恶心、呕吐和最严重宿醉症状的受试者中观察到最高的AVP值。在宿醉期间，血浆AVP值高于对照组，并且血浆AVP对直立姿势的反应被夸大。血浆AVP浓度与乙醇利尿的分离表明，AVP释放的抑制不是乙醇利尿的唯一决定因素。该研究可能表明，乙醇的毒性作用和宿醉症状的严重程度与水合状态和AVP触发机制的个体敏感性有关。
