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评估干预措施对传染病控制的影响:社区流动性降低对新冠病毒传播的影响。

Estimating intervention effects on infectious disease control: The effect of community mobility reduction on Coronavirus spread.

作者信息

Giffin Andrew, Gong Wenlong, Majumder Suman, Rappold Ana G, Reich Brian J, Yang Shu

机构信息

North Carolina State University, Department of Statistics, 2311 Stinson Drive, Raleigh, NC 27607, United States of America.

Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States of America.

出版信息

Spat Stat. 2022 Dec;52:100711. doi: 10.1016/j.spasta.2022.100711. Epub 2022 Oct 21.

Abstract

Understanding the effects of interventions, such as restrictions on community and large group gatherings, is critical to controlling the spread of COVID-19. Susceptible-Infectious-Recovered (SIR) models are traditionally used to forecast the infection rates but do not provide insights into the causal effects of interventions. We propose a spatiotemporal model that estimates the causal effect of changes in community mobility (intervention) on infection rates. Using an approximation to the SIR model and incorporating spatiotemporal dependence, the proposed model estimates a direct and indirect (spillover) effect of intervention. Under an interference and treatment ignorability assumption, this model is able to estimate causal intervention effects, and additionally allows for spatial interference between locations. Reductions in community mobility were measured by cell phone movement data. The results suggest that the reductions in mobility decrease Coronavirus cases 4 to 7 weeks after the intervention.

摘要

了解诸如限制社区和大型群体集会等干预措施的效果对于控制新冠病毒的传播至关重要。传统上,易感-感染-康复(SIR)模型用于预测感染率,但无法洞察干预措施的因果效应。我们提出了一种时空模型,该模型可估计社区流动性变化(干预措施)对感染率的因果效应。通过对SIR模型进行近似并纳入时空依赖性,所提出的模型估计了干预措施的直接和间接(溢出)效应。在干扰和治疗可忽略性假设下,该模型能够估计因果干预效应,并且还考虑了不同地点之间的空间干扰。社区流动性的降低通过手机移动数据来衡量。结果表明,流动性的降低在干预措施实施4至7周后可减少冠状病毒病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf1/9584839/5c5925c7564b/gr1_lrg.jpg

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