School of Mechatronical Engineering, Beijing Institute of Technology, Room 711, Building No 6, Science and Technology Park, 5 Zhongguancun South St, Haidian District, Beijing, 100081, China.
Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing, 100081, China.
Chem Soc Rev. 2022 Nov 14;51(22):9203-9242. doi: 10.1039/d2cs00359g.
The rapid development of micromanipulation technologies has opened exciting new opportunities for the actuation, selection and assembly of a variety of non-biological and biological nano/micro-objects for applications ranging from microfabrication, cell analysis, tissue engineering, biochemical sensing, to nano/micro-machines. To date, a variety of precise, flexible and high-throughput manipulation techniques have been developed based on different physical fields. Among them, optoelectronic tweezers (OET) is a state-of-art technique that combines light stimuli with electric field together by leveraging the photoconductive effect of semiconductor materials. Herein, the behavior of micro-objects can be directly controlled by inducing the change of electric fields on demand in an optical manner. Relying on this light-induced electrokinetic effect, OET offers tremendous advantages in micromanipulation such as programmability, flexibility, versatility, high-throughput and ease of integration with other characterization systems, thus showing impressive performance compared to those of many other manipulation techniques. A lot of research on OET have been reported in recent years and the technology has developed rapidly in various fields of science and engineering. This work provides a comprehensive review of the OET technology, including its working mechanisms, experimental setups, applications in non-biological and biological scenarios, technology commercialization and future perspectives.
微操作技术的飞速发展为各种非生物和生物纳米/微物体的驱动、选择和组装开辟了令人兴奋的新机会，其应用范围从微加工、细胞分析、组织工程、生化传感到纳米/微机器。迄今为止，已经基于不同的物理场开发了各种精确、灵活和高通量的操作技术。其中，光电镊（OET）是一种最先进的技术，它通过利用半导体材料的光导效应将光刺激与电场结合在一起。在此，通过以光学方式按需诱导电场的变化，可以直接控制微物体的行为。依靠这种光致动电动效应，OET 在微操作中具有巨大的优势，例如可编程性、灵活性、多功能性、高通量以及与其他表征系统的易于集成性，因此与许多其他操作技术相比具有令人印象深刻的性能。近年来，已经有大量关于 OET 的研究报告，该技术在科学和工程的各个领域都得到了迅速发展。本工作全面综述了 OET 技术，包括其工作机制、实验装置、在非生物和生物场景中的应用、技术商业化和未来展望。
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