Cardoso-Martins Inês, Arantes-Oliveira Sofia, Coelho Ana, Pessanha Sofia, F Marques Paula
Faculdade de Medicina Dentária, Universidade de Lisboa, Rua Professora Teresa Ambrósio, 1600-277 Lisbon, Portugal.
Department of Physics, NOVA School of Science and Technology, Campus Caparica, 2829-516 Caparica, Portugal.
Dent J (Basel). 2022 Oct 2;10(10):186. doi: 10.3390/dj10100186.
Remineralization of tooth enamel can be partially achieved by the application of a casein phosphopeptides and amorphous phosphate (CPP-ACP) complex. However, evidence to support its effectiveness in Molar-incisor-hypomineralization (MIH)-affected teeth is scarce. The study’s aim is to evaluate the efficacy of CPP-ACP mousse in remineralizing MIH-affected enamel using a Vickers microhardness test. Two groups of enamel opacities of hypomineralized permanent teeth, white (group A) and yellow (group B) lesions (n = 14), went through a 28-day treatment protocol with GC Tooth Mousse. Before and after treatment, microhardness was measured in three different areas of each tooth (hypomineralized, transition, and outside the hypomineralized area). Data were analyzed using parametric and non-parametric tests with a significance of p < 0.05. The mean microhardness values increased in the hypomineralized and transition areas in both groups after the treatment protocol (in group A, 105.38 ± 11.70 to 158.26 ± 37.34; 123.04 ± 22.84 to 156.33 ± 35.70; in group B, 108.63 ± 14.66 to 143.06 ± 22.81; 132.55 ± 20.66 to 146.00 ± 12.88) and the differences pre/post-treatment were statistically significant within each group (p < 0.001 for both groups). Between groups, there was a statistically significant difference in the same areas (hypomineralized: p = 0.003; transition: p = 0.008) with a higher improvement in enamel hardness in group A. Topical application of CPP-ACP showed an increase in the physical strength of the hypomineralized and transition areas of MIH-affected enamel, likely due to an increase in mineral content.
通过应用酪蛋白磷酸肽与无定形磷酸盐（CPP-ACP）复合物可部分实现牙釉质再矿化。然而，支持其对磨牙-切牙低矿化（MIH）患牙有效性的证据却很稀少。本研究的目的是使用维氏显微硬度测试评估CPP-ACP慕斯对MIH患牙釉质再矿化的疗效。两组低矿化恒牙釉质混浊，白色（A组）和黄色（B组）病变（n = 14），采用GC护齿慕斯进行为期28天的治疗方案。治疗前后，在每颗牙齿的三个不同区域（低矿化区、过渡区和低矿化区外）测量显微硬度。使用参数检验和非参数检验分析数据，显著性水平为p < 0.05。治疗方案后，两组低矿化区和过渡区的平均显微硬度值均增加（A组，从105.38±11.70至158.26±37.34；从123.04±22.84至156.33±35.70；B组，从108.63±14.66至143.06±22.81；从132.55±20.66至146.00±12.88），且每组治疗前后的差异具有统计学意义（两组均为p < 0.001）。两组之间，相同区域存在统计学显著差异（低矿化区：p = 0.003；过渡区：p = 0.008），A组釉质硬度改善更高。局部应用CPP-ACP显示MIH患牙釉质低矿化区和过渡区的物理强度增加，可能是由于矿物质含量增加所致。
