Li Zhangkang, Yu Cheng, Kumar Hitendra, He Xiao, Lu Qingye, Bai Huiyu, Kim Keekyoung, Hu Jinguang
Department of Biomedical Engineering, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Gels. 2022 Oct 21;8(10):682. doi: 10.3390/gels8100682.
The development of adhesive hydrogel materials has brought numerous advances to biomedical engineering. Hydrogel adhesion has drawn much attention in research and applications. In this paper, the study of hydrogel adhesion is no longer limited to the surface of hydrogels. Here, the effect of the internal crosslinking degree of hydrogels prepared by different methods on hydrogel adhesion was explored to find the generality. The results show that with the increase in crosslinking degree, the hydrogel adhesion decreased significantly due to the limitation of segment mobility. Moreover, two simple strategies to improve hydrogel adhesion generated by hydrogen bonding were proposed. One was to keep the functional groups used for hydrogel adhesion and the other was to enhance the flexibility of polymer chains that make up hydrogels. We hope this study can provide another approach for improving the hydrogel adhesion generated by hydrogen bonding.
粘性水凝胶材料的发展给生物医学工程带来了诸多进步。水凝胶粘附在研究和应用中备受关注。在本文中，对水凝胶粘附的研究不再局限于水凝胶表面。在此，探究了不同方法制备的水凝胶内部交联度对水凝胶粘附的影响，以找出其普遍性。结果表明，随着交联度的增加，由于链段迁移率受限，水凝胶粘附力显著下降。此外，还提出了两种通过氢键提高水凝胶粘附力的简单策略。一种是保留用于水凝胶粘附的官能团，另一种是增强构成水凝胶的聚合物链的柔韧性。我们希望这项研究能够为改善通过氢键产生的水凝胶粘附力提供另一种方法。
