Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran.
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran.
Mar Drugs. 2022 Sep 30;20(10):625. doi: 10.3390/md20100625.
The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealing that potential anticancer effects of marine agents could be achieved through the modulation of several organelles. Mitochondria are known organelles that influence growth, differentiation, and death of cells via influencing the biosynthetic, bioenergetic, and various signaling pathways related to oxidative stress and cellular metabolism. Consequently, mitochondria play an essential role in tumorigenesis and cancer treatments by adapting to alterations in environmental and cellular conditions. The growing interest in marine-derived anticancer agents, combined with the development and progression of novel technology in the extraction and cultures of marine life, led to revelations of new compounds with meaningful pharmacological applications. This is the first critical review on marine-derived anticancer agents that have the potential for targeting mitochondrial function during tumorigenesis. This study aims to provide promising strategies in cancer prevention and treatment.
海洋环境很重要，但通常研究不足。它包含了新的功能成分来源，可以影响食品加工、储存和强化过程中的各种途径。海洋微生物产生的生物活性次生代谢产物可能对人类有重要的潜在应用。从不同的海洋微生物中分离出的各种成分，包括真菌、微藻、细菌和黏菌，显示出相当大的生物效应，如抗癌、抗氧化、抗病毒、抗菌和神经保护活性。越来越多的研究表明，海洋药物的潜在抗癌作用可以通过调节几种细胞器来实现。线粒体是已知的细胞器，通过影响与氧化应激和细胞代谢相关的生物合成、生物能量和各种信号通路，影响细胞的生长、分化和死亡。因此，线粒体在肿瘤发生和癌症治疗中通过适应环境和细胞条件的变化起着至关重要的作用。对海洋来源的抗癌药物的兴趣日益浓厚，加上提取和培养海洋生物的新技术的发展和进步，揭示了具有有意义的药理学应用的新化合物。这是第一篇关于海洋来源的抗癌药物的重要综述，这些药物有可能在肿瘤发生过程中靶向线粒体功能。本研究旨在为癌症的预防和治疗提供有前途的策略。
