PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Mar Drugs. 2021 Apr 6;19(4):206. doi: 10.3390/md19040206.
The marine sponge of the genus , , , and are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H () and rhabdastin I (). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds and showed activities against K562 (IC 11.7 and 9.8 μM) and Molt4 (IC 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.
属于的海洋海绵以多种异马巴烷型三萜类化合物为特征。由于其具有显著的抗增殖特性，这类化合物在海洋药物发现中备受关注。进一步研究其化学多样性，鉴定出两种新的异马巴烷型三萜类化合物 rhabdastin H () 和 rhabdastin I ()。通过一系列光谱方法揭示了它们的结构。这些分离物具有独特的结构特征，是所有海洋来源的异马巴烷中唯一报道的四氢呋喃官能团。化合物 和 对 K562（IC 11.7 和 9.8 μM）和 Molt4（IC 16.5 和 11.0 μM）白血病细胞在 MTT 细胞增殖测定中表现出活性。
