格利菲斯系统：细菌性脑膜炎的潜在关键因素
The Glymphatic System: a Potential Key Player in Bacterial Meningitis.
机构信息
Dipartimento di Farmacia e Biotecnologie, Università di Bologna, Bologna, Italy.
Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
出版信息
mBio. 2022 Dec 20;13(6):e0235022. doi: 10.1128/mbio.02350-22. Epub 2022 Oct 26.
The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S. Generoso, S. Thorsdottir, A. Collodel, R. R. E. Santo, et al. (mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22) have now associated impaired glymphatic system functionality to neurological sequelae of murine meningitis caused by Streptococcus pneumoniae. Their work provides an initial and important step into the systematic evaluation of a potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
神经胶质淋巴系统（glymphatic system）是新近被描述的中枢神经系统的一种液体清除途径。神经胶质淋巴系统功能障碍导致脑脊液引流缺陷与几种神经疾病有关。在他们的文章中，J. S. Generoso、S. Thorsdottir、A. Collodel、R. R. E. Santo 等人（mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22）将功能障碍的神经胶质淋巴系统与肺炎链球菌引起的小鼠脑膜炎的神经后遗症联系起来。他们的工作为系统评估神经胶质淋巴系统功能对脑膜炎严重程度和后遗症的潜在影响提供了初步且重要的一步。
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