[ACTIV SARS-CoV-2注册研究（成人患者新冠病毒感染后慢性非传染性疾病动态分析）。评估新冠病毒感染患者合并的原有共病对预后的影响]

[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].

作者信息

Arutyunov G P, Tarlovskaya E I, Arutyunov A G, Belenkov Y N, Konradi A O, Lopatin Y M, Rebrov A P, Tereshchenko S N, Chesnikova A I, Hayrapetyan H G, Babin A P, Bakulin I G, Bakulina N V, Balykova L A, Blagonravova A S, Boldina M V, Vaisberg A R, Galyavich A S, Gomonova V V, Grigorieva N Y, Gubareva I V, Demko I V, Evzerikhina A V, Zharkov A V, Kamilova U K, Kim Z F, Kuznetsova T Y, Lareva N V, Makarova E V, Malchikova S V, Nedogoda S V, Petrova M M, Pochinka I G, Protasov K V, Protsenko D N, Ruzanau D Y, Sayganov S A, Sarybaev A S, Selezneva N M, Sugraliev A B, Fomin I V, Khlynova O V, Chizhova O Y, Shaposhnik I I, Sh'ukarev D A, Abdrahmanova А K, Avetisian S A, Avoyan H G, Azarian K K, Aimakhanova G T, Ayipova D A, Akunov A C, Alieva M K, Aparkina A V, Aruslanova O R, Ashina E Y, Badina O Y, Barisheva O Y, Batchayeva A S, Bitieva A M, Bikhteyev I U, Borodulina N A, Bragin M V, Budu A M, Bykova G M, Vagapova K R, Varlamova D D, Vezikova N N, Verbitskaya E A, Vilkova O E, Vinnikova E A, Vustina V V, Galova E A, Genkel V V, Gorshenina E I, Gostishev R V, Grigorieva E V, Gubareva E Y, Dabylova G M, Demchenko A I, Dolgikh O Y, Duyshobayev M Y, Evdokimov D S, Egorova K E, Ermilova A N, Zheldybayeva A E, Zarechnova N V, Zimina Y D, Ivanova S Y, Ivanchenko E Y, Ilina M V, Kazakovtseva M V, Kazymova E V, Kalinina Y S, Kamardina N A, Karachenova A M, Karetnikov I A, Karoli N A, Karsiev M K, Кaskaeva D S, Kasymova K F, Kerimbekova Z B, Kerimova A S, Kim E S, Kiseleva N V, Klimenko D A, Klimova A V, Kovalishena O V, Kolmakova E V, Kolchinskaya T P, Kolyadich M I, Kondriakova O V, Konoval M P, Konstantinov D Y, Konstantinova E A, Kordukova V A, Koroleva E V, Kraposhina A Y, Kriukova T V, Kuznetsova A S, Kuzmina T Y, Kuzmichev K V, Kulchoroevna C K, Kuprina T V, Kouranova I M, Kurenkova L V, Kurchugina N Y, Kushubakova N A, Levankova V I, Lyubavina N A, Magdeyeva N A, Mazalov K V, Majseenko V I, Makarova A S, Maripov A M, Marusina A A, Melnikov E S, Moiseenko N B, Muradova F N, Muradyan R G, Musaelian S N, Myshak A O, Nekaeva E S, Nikitina N M, Ogurlieva B B, Odegova A A, Omarova Y V, Omurzakova N A, Ospanova S O, Pahomova E V, Petrov L D, Plastinina S S, Pogrebetskaya V A, Polyakov D S, Ponomarenko E V, Popova L L, Prokofeva N A, Pudova I A, Rakov N A, Rahimov A N, Rozanova N A, Serikbolkyzy S, Simonov A A, Skachkova V V, Soloveva D V, Soloveva I A, Subbotin A K, Sukhomlinova I M, Sushilova A G, Tagayeva D R, Titojkina Y V, Tikhonova E P, Tokmin D S, Tolmacheva A A, Torgunakova M S, Trenogina K V, Trostianetckaia N A, Trofimov D A, Tulichev A A, Tursunova A T, Ulanova N D, Fatenkov O V, Fedorishina O V, Fil T S, Fomina I Y, Fominova I S, Frolova I A, Tsvinger S M, Tsoma V V, Cholponbaeva M B, Chudinovskikh T I, Shevchenko O A, Sheshina T V, Shishkina E A, Shishkov K Y, Sherbakov S Y, Yausheva E A

机构信息

Eurasian Association of Therapists.

Pirogov Russian National Research Medical University.

出版信息

Ter Arkh. 2022 Jan 15;94(1):32-47. doi: 10.26442/00403660.2022.01.201320.

DOI:10.26442/00403660.2022.01.201320

PMID:36286918

Abstract

AIM

Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.

MATERIALS AND METHODS

The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.

CLINICALTRIALS

gov ID NCT04492384.

RESULTS

Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.

CONCLUSION

Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.

摘要

目的

研究新冠病毒感染患者中各种合并原发疾病组合对新型冠状病毒感染疾病进展及预后的影响。

材料与方法

ACTIV登记册是在欧亚治疗师协会的倡议下创建的。登记册纳入了5808名患者：在医院或家中接受治疗的新冠病毒感染的男性和女性。

临床试验

美国国立医学图书馆临床试验注册号NCT04492384。

结果

大多数新冠病毒感染患者患有原发合并疾病（oCDs）。通过简单计算oCDs评估的多病共存是新冠病毒感染不良预后的独立因素。对2种、3种和4种oCDs最常见组合的研究发现，心血管疾病（所有可能的变体）占绝对主导地位。2种oCDs最不利的组合包括心房高血压（AH）和慢性心力衰竭（CHF）。3种oCDs最不利的组合包括AH、冠心病（CHD）和CHF；4种oCDs最糟糕的组合包括AH、CHD、CHF和糖尿病。这些组合分别使死亡风险增加3.963倍、4.082倍和4.215倍。