Gibiino Giulia, Binda Cecilia, Cristofaro Ludovica, Sbrancia Monica, Coluccio Chiara, Petraroli Chiara, Jung Carlo Felix Maria, Cucchetti Alessandro, Cavaliere Davide, Ercolani Giorgio, Sambri Vittorio, Fabbri Carlo
Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, Ausl Romagna, 47121 Forlì-Cesena, Italy.
Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
Biomedicines. 2022 Oct 10;10(10):2532. doi: 10.3390/biomedicines10102532.
Surgery of the gastrointestinal tract can result in deep changes among the gut commensals in terms of abundance, function and health consequences. Elective colorectal surgery can occur for neoplastic or inflammatory bowel disease; in these settings, microbiota imbalance is described as a preoperative condition, and it is linked to post-operative complications, as well. The study of bariatric patients led to several insights into the role of gut microbiota in obesity and after major surgical injuries. Preoperative dysbiosis and post-surgical microbiota reassessment are still poorly understood, and they could become a key part of preventing post-surgical complications. In the current review, we outline the most recent literature regarding agents and molecular pathways involved in pre- and post-operative dysbiosis in patients undergoing gastrointestinal surgery. Defining the standard method for microbiota assessment in these patients could set up the future approach and clinical practice.
胃肠道手术可导致肠道共生菌在数量、功能及健康影响方面发生深刻变化。择期结直肠手术可因肿瘤性或炎症性肠病而进行；在这些情况下，微生物群失衡被描述为术前状态，并且它也与术后并发症有关。对肥胖症患者的研究使人们对肠道微生物群在肥胖症及重大手术创伤后的作用有了若干认识。术前的生态失调及术后微生物群的重新评估仍未得到充分了解，它们可能会成为预防术后并发症的关键部分。在本综述中，我们概述了有关胃肠道手术患者术前和术后生态失调所涉及的因素及分子途径的最新文献。确定这些患者微生物群评估的标准方法可为未来的方法和临床实践奠定基础。
