College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211800, China.
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China.
Biosensors (Basel). 2022 Oct 4;12(10):823. doi: 10.3390/bios12100823.
Transition metal sulfides have been explored as electrode materials for non-enzymatic detection. In this work, we investigated the effects of phosphorus doping on the electrochemical performances of NiCoS electrodes (P-NiCoS) towards glucose oxidation. The fabricated non-enzymatic biosensor displayed better sensing performances than pristine NiCoS, with a good sensitivity of 250 µA mM cm, a low detection limit (LOD) of 0.46 µM (S/N = 3), a wide linear range of 0.001 to 5.2 mM, and high selectivity. Moreover, P-NiCoS demonstrated its feasibility for glucose determination for practical sample testing. This is due to the fact that the synergetic effects between Ni and Co species, and the partial substitution of S vacancies with P can help to increase electronic conductivity, enrich binary electroactive sites, and facilitate surface electroactivity. Thus, it is found that the incorporation of dopants into NiCoS is an effective strategy to improve the electrochemical activity of host materials.
过渡金属硫化物已被探索作为非酶检测的电极材料。在这项工作中，我们研究了磷掺杂对 NiCoS 电极（P-NiCoS）电化学性能的影响，以用于葡萄糖氧化。所制备的非酶生物传感器在葡萄糖氧化方面表现出比原始 NiCoS 更好的传感性能，具有 250 µA mM cm 的良好灵敏度、0.46 µM（S/N = 3）的低检测限、0.001 至 5.2 mM 的宽线性范围和高选择性。此外，P-NiCoS 还展示了其在实际样品测试中用于葡萄糖测定的可行性。这是因为 Ni 和 Co 物种之间的协同效应，以及 S 空位的部分取代与 P 有助于提高电子导电性、丰富二元电活性位点，并促进表面电活性。因此，发现将掺杂剂掺入 NiCoS 是提高宿主材料电化学活性的有效策略。
