Morello Rosa, De Rose Cristina, Cardinali Sara, Valentini Piero, Buonsenso Danilo
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli", IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy.
Department of Laboratory and Infectious Sciences, Università del Sacro Cuore, 20123 Rome, Italy.
Children (Basel). 2022 Sep 22;9(10):1446. doi: 10.3390/children9101446.
Long COVID is an emergent, heterogeneous, and multisystemic condition with an increasingly important impact also on the pediatric population. Among long COVID symptoms, patients can experience chronic gastrointestinal symptoms such as abdominal pain, constipation, diarrhea, vomiting, nausea, and dysphagia. Although there is no standard, agreed, and optimal diagnostic approach or treatment of long COVID in children, recently compounds containing multiple micronutrients and lactoferrin have been proposed as a possible treatment strategy, due to the long-standing experience gained from other gastrointestinal conditions. In particular, lactoferrin is a pleiotropic glycoprotein with antioxidant, anti-inflammatory, antithrombotic, and immunomodulatory activities. Moreover, it seems to have several physiological functions to protect the gastrointestinal tract. In this regard, we described the resolution of symptoms after the start of therapy with high doses of oral lactoferrin in two patients referred to our post-COVID pediatric unit due to chronic gastrointestinal symptoms after SARS-CoV-2 infection.
长期新冠是一种新出现的、异质性的多系统疾病，对儿童群体的影响也日益重要。在长期新冠症状中，患者可能会出现慢性胃肠道症状，如腹痛、便秘、腹泻、呕吐、恶心和吞咽困难。尽管目前对于儿童长期新冠尚无标准的、公认的最佳诊断方法或治疗方法，但由于从其他胃肠道疾病中积累的长期经验，最近有人提出含有多种微量营养素和乳铁蛋白的化合物可能是一种治疗策略。特别是，乳铁蛋白是一种具有抗氧化、抗炎、抗血栓和免疫调节活性的多效糖蛋白。此外，它似乎具有多种保护胃肠道的生理功能。在这方面，我们描述了两名因感染SARS-CoV-2后出现慢性胃肠道症状而转诊至我们新冠后儿科病房的患者，在开始高剂量口服乳铁蛋白治疗后症状得到缓解的情况。
