Aldisi Dara, Abulmeaty Mahmoud M A, Alsaawi Tafany A, Alorf Abeer S, Mujlli Gadah, Alshahrani Atheer M, Alahmari Rajwa M, Alquraishi Mohammed, Al-Daghri Nasser M, Alruwaili Nawaf W, Sabico Shaun
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh P.O. Box 11362, Saudi Arabia.
Biochemistry Department, College of Science, King Saud University, Riyadh P.O. Box 11451, Saudi Arabia.
Diagnostics (Basel). 2022 Sep 23;12(10):2293. doi: 10.3390/diagnostics12102293.
Several studies have found a correlation between inflammatory markers and sarcopenia; however, limited research has been conducted on the Arabic population. Therefore, this study aimed to investigate the value of inflammatory parameters in Saudi elderly women with sarcopenia. In this cross-sectional study, 76 elderly Saudi women (>65 years) were stratified according to the presence (n = 26) or absence (n = 50) of sarcopenia, using the operational definition of the Asian Working Group for Sarcopenia (AWGS). Demographics and clinical data were collected. Muscle mass, muscle strength, and physical performance were assessed using bioelectrical impedance, hand grip and timed-up-and-go (TUG) tests, respectively. Inflammatory markers such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP) were assessed using commercially available assays. Muscle mass and strength indicators were lower in the sarcopenia group (p-value < 0.05). Moreover, interleukin 6 (IL-6) was positively correlated with TUG (r = 0.48, p-value < 0.05), while CRP showed an inverse correlation with the right leg muscle (R-Leg-M) and a positive correlation with triceps skinfold (TSF) (r = −0.41, r = 0.42, respectively, p-values < 0.05). Additionally, TSF and R-Leg-M were independent predictors of CRP variation (R2 = 0.35; p < 0.01). Lastly, participants with a TNF-α > 71.2 were five times more likely to have sarcopenia [(OR = 5.85), 95% CI: 1.07−32.08; p = 0.04]. In conclusion, elevated levels of TNF-α are significantly associated with the risk of sarcopenia, while variations perceived in circulating CRP can be explained by changes in the muscle mass indices only among individuals with sarcopenia. The present findings, while promising, need further investigations on a larger scale to determine whether inflammatory markers hold any diagnostic value in assessing sarcopenia among elderly Arab women.
多项研究发现炎症标志物与肌肉减少症之间存在关联；然而，针对阿拉伯人群的研究有限。因此，本研究旨在调查炎症参数在患有肌肉减少症的沙特老年女性中的价值。在这项横断面研究中，根据亚洲肌肉减少症工作组（AWGS）的操作定义，将76名沙特老年女性（>65岁）按照是否存在肌肉减少症分为两组，存在肌肉减少症的26名（n = 26），不存在肌肉减少症的50名（n = 50）。收集了人口统计学和临床数据。分别使用生物电阻抗、握力和定时起立行走（TUG）测试评估肌肉质量、肌肉力量和身体表现。使用市售检测方法评估炎症标志物，如白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）。肌肉减少症组的肌肉质量和力量指标较低（p值<0.05）。此外，白细胞介素6（IL-6）与TUG呈正相关（r = 0.48，p值<0.05），而CRP与右腿肌肉（R-Leg-M）呈负相关，与三头肌皮褶厚度（TSF）呈正相关（分别为r = -0.41，r = 0.42，p值<0.05）。此外，TSF和R-Leg-M是CRP变化的独立预测因素（R2 = 0.35；p < 0.01）。最后，TNF-α>71.2的参与者患肌肉减少症的可能性是其他人的五倍[（OR = 5.85），95%CI：1.07−32.08；p = 0.04]。总之，TNF-α水平升高与肌肉减少症风险显著相关，而循环CRP的变化仅在患有肌肉减少症的个体中可由肌肉质量指数的变化来解释。本研究结果虽然很有前景，但需要进一步进行大规模调查，以确定炎症标志物在评估老年阿拉伯女性肌肉减少症方面是否具有诊断价值。
