Al-Daghri Nasser M, Al-Shuwaie Albatul Y A, Alghamdi Amani, Amer Osama E, Khattak Malak N K, Ansari Mohammed G A, Alnaami Abdullah M, Sabico Shaun
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Biology (Basel). 2021 Jun 18;10(6):550. doi: 10.3390/biology10060550.
Tristetraprolin (TTP) is an mRNA binding protein suggested to have a substantial role in regulating the mRNA expression of numerous inflammatory factors, but data on TTP and its association with metabolic syndrome (MetS), a chronic low-grade inflammatory disorder, are scarce. We hypothesize that TTP may modulate MetS and its components. A total of 200 Saudi adults (aged 38.6 ± 8.3 years) were included in this cross-sectional study. Anthropometrics data were collected and fasting blood glucose taken for the assessment of glycemic, lipids and inflammatory markers using commercially available assays. The National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria were used to define MetS. Results showed significantly higher levels of TTP in the MetS group than in controls [288.1 pg/mL vs. 150.9 pg/mL, < 0.001]. Circulating TTP was significantly associated with tumor necrosis factor alpha [TNF-α, R = 0.30, < 0.05], interleukin 1β [IL-1β, R = 0.41, < 0.01] and C-reactive protein [CRP, R = 0.36, < 0.01], adiponectin [R = 0.36, < 0.05], insulin [R = 0.37, < 0.05], and insulin resistance [HOMA-IR, R = 0.40, < 0.05]. Receiver operating characteristics (ROC) suggest a potential use of TTP as diagnostic biomarker for MetS [AUC = 0.819, < 0.001]. The findings suggest that TTP is associated with inflammation and glycemia, which may influence MetS. TTP is a promising diagnostic biomarker for MetS which can be confirmed in larger cohorts.
锌指蛋白36（ZFP36）是一种mRNA结合蛋白，被认为在调节多种炎症因子的mRNA表达中发挥重要作用，但关于ZFP36及其与代谢综合征（MetS）（一种慢性低度炎症性疾病）关联的数据却很匮乏。我们推测ZFP36可能调节代谢综合征及其组成部分。本横断面研究共纳入了200名沙特成年人（年龄38.6±8.3岁）。收集人体测量学数据，并采集空腹血糖，使用市售检测方法评估血糖、血脂和炎症标志物。采用美国国家胆固醇教育计划成人治疗小组（NCEP ATP III）标准来定义代谢综合征。结果显示，代谢综合征组的ZFP36水平显著高于对照组[288.1 pg/mL对150.9 pg/mL，<0.001]。循环ZFP36与肿瘤坏死因子α[TNF-α，R=0.30，<0.05]、白细胞介素1β[IL-1β，R=0.41，<0.01]、C反应蛋白[CRP，R=0.36，<0.01]、脂联素[R=0.36，<0.05]、胰岛素[R=0.37，<0.05]以及胰岛素抵抗[HOMA-IR，R=0.40，<0.05]显著相关。受试者工作特征曲线（ROC）表明ZFP36有可能作为代谢综合征的诊断生物标志物[AUC=0.819，<0.001]。这些发现表明，ZFP36与炎症和血糖相关，这可能会影响代谢综合征。ZFP36是一种有前景的代谢综合征诊断生物标志物，这一点可在更大规模的队列研究中得到证实。
