Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, P.R. China.
Ann Med. 2024 Dec;56(1):2384664. doi: 10.1080/07853890.2024.2384664. Epub 2024 Aug 22.
Observational studies have documented increased serum IL-6 levels in elderly individuals afflicted with sarcopenia. Nevertheless, the relationship between serum IL-6 concentrations and sarcopenia prevalence in the aging population is yet to be defined.
We executed a systematic review and meta-analysis of cross-sectional studies that scrutinized serum IL-6 levels in older adults with and without sarcopenia. Relevant studies were sourced from PubMed, Scopus, Embase, Cochrane Library, and Web of Science from inception until 10 September 2023. The standard mean differences (SMDs) in serum IL-6 levels between studies were synthesized using a random-effects model. To examine the influence of demographic and clinical factors on these outcomes, we performed subgroup analyses and meta-regression, focusing on variables such as sex, age, and body mass index (BMI). We also assessed the relationship between serum IL-6 levels and the defining components of sarcopenia: muscle mass, muscle strength, and physical performance. We used Fisher's Z transformation to standardize the interpretation of effect sizes from these relationships. The transformed values were then converted to summary correlation coefficients (r) for a clear and unified summary of the results.
We included twenty-one cross-sectional studies involving 3,902 participants. Meta-analysis revealed significantly elevated serum IL-6 levels in older adults with sarcopenia compared with those without sarcopenia (SMD = 0.31; 95% CI 0.18, 0.44). The difference was highly pronounced in the subgroups of male and those with female percentage below 50% or a mean BMI below 24 kg/m. Serum IL-6 levels were inversely correlated with muscle mass (summary r = -0.18; 95% CI -0.30, -0.06), but not with handgrip strength (summary r = -0.10; 95%CI: -0.25, 0.05) or gait speed (summary r = -0.09; 95%CI: -0.24, 0.07).
This meta-analysis establishes a link between increased serum IL-6 levels and sarcopenia in the elderly, particularly in relation to decreased muscle mass.
观察性研究已经记录了患有肌少症的老年人血清 IL-6 水平升高。然而，衰老人群中血清 IL-6 浓度与肌少症患病率之间的关系尚未确定。
我们对研究老年人肌少症和非肌少症患者血清 IL-6 水平的横断面研究进行了系统回顾和荟萃分析。从 PubMed、Scopus、Embase、Cochrane 图书馆和 Web of Science 中检索从成立到 2023 年 9 月 10 日的相关研究。使用随机效应模型综合研究中血清 IL-6 水平的标准均数差值 (SMD)。为了研究人口统计学和临床因素对这些结果的影响，我们进行了亚组分析和荟萃回归，重点关注性别、年龄和体重指数 (BMI) 等变量。我们还评估了血清 IL-6 水平与肌少症定义成分之间的关系：肌肉质量、肌肉力量和身体表现。我们使用 Fisher Z 转换将这些关系的效应大小标准化，然后将转换值转换为汇总相关系数 (r)，以便清晰统一地总结结果。
我们纳入了 21 项横断面研究，涉及 3902 名参与者。荟萃分析显示，与非肌少症患者相比，肌少症老年人的血清 IL-6 水平显著升高 (SMD=0.31；95%CI 0.18，0.44)。在男性亚组和女性比例低于 50%或平均 BMI 低于 24 kg/m 的亚组中，差异更为显著。血清 IL-6 水平与肌肉质量呈负相关 (汇总 r=-0.18；95%CI-0.30，-0.06)，但与握力 (汇总 r=-0.10；95%CI：-0.25，0.05)或步态速度 (汇总 r=-0.09；95%CI：-0.24，0.07)无关。
这项荟萃分析确立了老年人体内血清 IL-6 水平升高与肌少症之间的联系，尤其是与肌肉质量下降有关。
