Chen Hong, Huang Haozhe, Zhang Jianye, Wang Xuexue, Han Mengyang, Ding Chanjun, Wang Jinhong
Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Department of Interventional Radiology, Fudan University Shanghai Cancer Center, 270 Dongan Road, Xuhui District, Shanghai 200032, China.
Diagnostics (Basel). 2022 Sep 26;12(10):2319. doi: 10.3390/diagnostics12102319.
(1) Background: Accurate measurement of lung-nodule size is necessary, but whether a three-dimensional volume measurement is better or more reliable than the one-dimensional method is still unclear. This study aimed to investigate the intra- and inter-reader variations according to nodule type, size, three-dimensional volume measurements, and one-dimensional linear measurements. (2) Methods: This retrospective study included computed tomography (CT) examinations of lung nodules and volume measurements performed from October to December 2016. Two radiologists independently performed all measurements. Intra-class correlation coefficients (ICC) and Bland-Altman plots were used for analysis. (3) Results: The overall variability in the calculated volume was larger than when using the semiautomatic volume measurement. Nodules <6 mm tended to have larger variability than nodules ≥6 mm in both one-dimensional and calculated volume measurements. The isolated type showed smaller variability in both intra- and inter-reader comparisons. The juxta-vascular type showed the largest variability in both one-dimensional and calculated volume measurements. The variability was decreased when using the 3D volume semiautomated software. (4) Conclusions: The present study suggests that 3D semiautomatic volume measurements showed lower variability than the calculated volume measurement. Nodule size and location influence measurement variability. The intra- and inter-reader variabilities in nodule volume measurement were considerable.
(1) 背景：准确测量肺结节大小很有必要，但三维体积测量是否比一维测量方法更好或更可靠仍不明确。本研究旨在调查根据结节类型、大小、三维体积测量和一维线性测量的阅片者内和阅片者间差异。(2) 方法：这项回顾性研究纳入了2016年10月至12月进行的肺结节计算机断层扫描（CT）检查及体积测量。两名放射科医生独立进行所有测量。采用组内相关系数（ICC）和布兰德-奥特曼图进行分析。(3) 结果：计算体积的总体变异性大于使用半自动体积测量时的变异性。在一维测量和计算体积测量中，<6 mm的结节往往比≥6 mm的结节变异性更大。在阅片者内和阅片者间比较中，孤立型结节的变异性较小。血管旁型结节在一维测量和计算体积测量中变异性最大。使用三维体积半自动软件时变异性降低。(4) 结论：本研究表明，三维半自动体积测量的变异性低于计算体积测量。结节大小和位置会影响测量变异性。结节体积测量的阅片者内和阅片者间变异性相当大。
