Sun Chengxian, Li Shunjia, Wang Kai, Yin Xinming, Wang Yanmei, Du Mengfang, Wei Jizhen, An Shiheng
Henan International Laboratory for Green Pest Control, College of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China.
College of Forestry, Henan Agricultural University, Zhengzhou 450002, China.
Insects. 2022 Oct 21;13(10):965. doi: 10.3390/insects13100965.
The long-term use of chemical insecticides has caused serious problems of insect resistance and environmental pollution; new insecticides are needed to solve this problem. Cyclosporin A (CsA) is a polypeptide produced by many fungi, which is used to prevent or treat immune rejection during organ transplantation. However, little is known about the utility of CsA as an insecticide. Therefore, this study evaluated the insecticidal activity of CsA using as a model. The results demonstrated that CsA was toxic to with LC values of 113.02 μg/g and 198.70 μg/g for newly hatched neonates and newly molted third-instar larvae, respectively. Furthermore, CsA treatment had sublethal effects on the development of , and significantly reduced the fecundity of adults; this suggests that CsA has great potential to suppress populations. Further analysis revealed that CsA suppressed calcineurin activity in larvae. CsA had independent or synergistic toxic effects on when combined with β-cypermethrin, indoxacarb, emamectin benzoate, azadirachtin, and the toxin Cry1Ac, which suggests that CsA can help prevent or manage resistance. Our study provides detailed information on the potential of CsA as an insecticide for controlling lepidopterans.
长期使用化学杀虫剂已导致严重的昆虫抗药性和环境污染问题；需要新型杀虫剂来解决这一问题。环孢菌素A（CsA）是许多真菌产生的一种多肽，用于预防或治疗器官移植过程中的免疫排斥反应。然而，关于CsA作为杀虫剂的效用知之甚少。因此，本研究以[具体昆虫名称未给出]为模型评估了CsA的杀虫活性。结果表明，CsA对[具体昆虫名称未给出]有毒性，新孵化的幼虫和刚蜕皮的三龄幼虫的LC值分别为113.02μg/g和198.70μg/g。此外，CsA处理对[具体昆虫名称未给出]的发育有亚致死效应，并显著降低了成虫的繁殖力；这表明CsA具有抑制[具体昆虫名称未给出]种群的巨大潜力。进一步分析表明，CsA抑制了幼虫中的钙调神经磷酸酶活性。CsA与高效氯氰菊酯、茚虫威、甲氨基阿维菌素苯甲酸盐、印楝素和苏云金芽孢杆菌毒素Cry1Ac联合使用时，对[具体昆虫名称未给出]具有独立或协同的毒性作用，这表明CsA有助于预防或管理抗药性。我们的研究提供了关于CsA作为控制鳞翅目害虫杀虫剂潜力的详细信息。
