Cyclosporin A as a Potential Insecticide to Control the Asian Corn Borer Guenée (Lepidoptera: Pyralidae).

The long-term use of chemical insecticides has caused serious problems of insect resistance and environmental pollution; new insecticides are needed to solve this problem. Cyclosporin A (CsA) is a polypeptide produced by many fungi, which is used to prevent or treat immune rejection during organ transplantation. However, little is known about the utility of CsA as an insecticide. Therefore, this study evaluated the insecticidal activity of CsA using as a model. The results demonstrated that CsA was toxic to with LC values of 113.02 μg/g and 198.70 μg/g for newly hatched neonates and newly molted third-instar larvae, respectively. Furthermore, CsA treatment had sublethal effects on the development of , and significantly reduced the fecundity of adults; this suggests that CsA has great potential to suppress populations. Further analysis revealed that CsA suppressed calcineurin activity in larvae. CsA had independent or synergistic toxic effects on when combined with β-cypermethrin, indoxacarb, emamectin benzoate, azadirachtin, and the toxin Cry1Ac, which suggests that CsA can help prevent or manage resistance. Our study provides detailed information on the potential of CsA as an insecticide for controlling lepidopterans.