ExCE Research Group, Department of Physical Education, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
Int J Environ Res Public Health. 2022 Oct 18;19(20):13469. doi: 10.3390/ijerph192013469.
Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD.
In total, 249 community-dwelling older adults aged 60-80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Fried criteria (muscle weakness; slow walking speed; low physical activity; unintentional weight loss; self-reported exhaustion). Participants with one or two standardized Fried criteria were classified as pre-frail and those with zero criteria as robust. Arterial stiffness was measured by aortic pulse wave velocity (aPWV). The data were analyzed using the generalized linear model.
From 249 participants (66.1 ± 5.3 years; 79.5% females), 61.8% ( = 154) were pre-frail and 38.2% ( = 95) robust. Pre-frail older adults had a higher aPWV (β = 0.19 m/s; = 0.007) compared to their robust peers.
The pre-frailty phenotype was associated with higher arterial stiffness in community-dwelling older adults aged 60-80 years. Pre-frail older adults may have a higher risk for CVD.
动脉僵硬度是心血管疾病（CVD）的一种亚临床标志物。衰弱前期表型与 CVD 风险增加相关。本研究旨在调查衰弱前期表型与无诊断为 CVD 的社区居住老年人的动脉僵硬度之间的关系。
本横断面研究共纳入 249 名年龄在 60-80 岁的社区居住老年人。衰弱前期表型通过标准化的 Fried 标准（肌肉无力；行走速度慢；体力活动少；非故意体重减轻；自我报告的疲倦）来定义。有一个或两个标准化 Fried 标准的患者被归类为衰弱前期，没有标准的患者被归类为稳健。动脉僵硬度通过主动脉脉搏波速度（aPWV）来测量。使用广义线性模型分析数据。
在 249 名参与者（66.1 ± 5.3 岁；79.5%为女性）中，61.8%（=154）为衰弱前期，38.2%（=95）为稳健。与稳健的同龄人相比，衰弱前期的老年人 aPWV 更高（β=0.19 m/s；=0.007）。
衰弱前期表型与社区居住的 60-80 岁老年人的动脉僵硬度增加有关。衰弱前期的老年人可能有更高的 CVD 风险。
