Karakousis Nikolaos D, Kotsiou Ourania S, Gourgoulianis Konstantinos I
Primary Healthcare, Internal Medicine Department, Amarousion, 15125 Athens, Greece.
Faculty of Nursing, University of Thessaly, 41500 Larissa, Greece.
J Pers Med. 2022 Sep 21;12(10):1556. doi: 10.3390/jpm12101556.
Sarcopenia seems to be an emerging health issue worldwide, concerning the progressive loss of skeletal muscle mass, accompanied by adverse outcomes. Asthma is a chronic inflammatory respiratory condition that is widespread in the world, affecting approximately 8% of adults. Although data are scarce, we aim to shed light on the potential association between low muscle mass and asthma and point out any probable negative feedback on each other.
We searched within the PubMed, Scopus, MEDLINE, and Google Scholar databases.
Three studies were included in our analysis. Only original studies written in English were included, while the references of the research articles were thoroughly examined for more relevant studies. Moreover, animal model studies were excluded.
2% to 17% of asthmatics had sarcopenia according to the existent literature. Sarcopenic asthmatic patients seem to have reduced lung function, while their mortality risk may be increased. Furthermore, patients with asthma- chronic obstructive pulmonary disease (COPD) overlap syndrome phenotype and sarcopenia might have a higher risk of osteopenia and osteoporosis progression, leading consequently to an increased risk of fractures and disability.
Emerging data support that pulmonologists should be aware of the sarcopenia concept and be prepared to evaluate the existence of low muscle mass in their asthmatic patients.
肌肉减少症似乎正成为一个全球性的新兴健康问题，它涉及骨骼肌质量的逐渐丧失，并伴有不良后果。哮喘是一种慢性炎症性呼吸道疾病，在全球广泛存在，约影响8%的成年人。尽管数据稀少，但我们旨在阐明低肌肉量与哮喘之间的潜在关联，并指出它们之间可能存在的任何负面反馈。
我们在PubMed、Scopus、MEDLINE和谷歌学术数据库中进行了检索。
三项研究纳入了我们的分析。仅纳入用英文撰写的原创研究，同时对研究文章的参考文献进行了全面审查以寻找更相关的研究。此外，动物模型研究被排除。
根据现有文献，2%至17%的哮喘患者存在肌肉减少症。肌肉减少性哮喘患者的肺功能似乎有所下降，其死亡风险可能增加。此外，患有哮喘-慢性阻塞性肺疾病（COPD）重叠综合征表型和肌肉减少症的患者可能有更高的骨质减少和骨质疏松进展风险，从而导致骨折和残疾风险增加。
新出现的数据支持肺科医生应了解肌肉减少症的概念，并准备好评估其哮喘患者中低肌肉量的存在情况。
