Zhang Lusi, Jacobson Pamala A, Johnson Alyssa N K, Gregornik David B, Johnson Steven G, McCarty Catherine A, Bishop Jeffrey R
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Medical Genetics and Genomics, Children's Minnesota, Minneapolis, MN 55404, USA.
J Pers Med. 2022 Sep 30;12(10):1615. doi: 10.3390/jpm12101615.
The clinical adoption and implementation of pharmacogenomics (PGx) beyond academic medical centers remains slow, restricting the general population from benefitting from this important component of personalized medicine. As an initial step in the statewide initiative of PGx implementation in Minnesota, we engaged community members and assessed attitudes towards PGx testing and acceptability of establishing a secure statewide PGx database for clinical and research use among Minnesota residents. Data was collected from 808 adult attendees at the 2021 Minnesota State Fair through an electronic survey. Eighty-four percent of respondents felt comfortable getting a PGx test for clinical care. Most respondents trusted health professionals (78.2%) and researchers (73.0%) to keep their PGx data private. The majority expressed their support and interest in participating in a statewide PGx database for clinical and research use (64-72%). Higher acceptability of the statewide PGx database was associated with younger age, higher education, higher health literacy, having health insurance, and prior genetic testing. The study sample representing Minnesota residents expressed high acceptability of receiving PGx testing and willingness to participate in PGx data sharing for clinical and research use. Community support and engagement are needed to advance PGx implementation and research on the state scale.
在学术医疗中心之外，药物基因组学（PGx）在临床中的应用和实施仍然缓慢，这使得普通民众无法从个性化医疗的这一重要组成部分中受益。作为明尼苏达州全州范围内实施PGx计划的第一步，我们与社区成员进行了接触，并评估了他们对PGx检测的态度以及在明尼苏达州居民中建立一个用于临床和研究的安全全州PGx数据库的可接受性。通过电子调查从2021年明尼苏达州博览会上的808名成年参与者中收集了数据。84%的受访者对接受PGx检测用于临床护理感到放心。大多数受访者信任医疗专业人员（78.2%）和研究人员（73.0%）会对他们的PGx数据保密。大多数人表示支持并愿意参与一个用于临床和研究的全州PGx数据库（64 - 72%）。对全州PGx数据库较高的可接受性与较年轻的年龄、较高的教育水平、较高的健康素养、拥有医疗保险以及先前的基因检测有关。代表明尼苏达州居民的研究样本对接受PGx检测以及参与临床和研究用PGx数据共享表示出较高的可接受性。需要社区的支持和参与来推动全州范围内PGx的实施和研究。
