Wang Lili, Wu Lifen, Qian Chunya, Ju Yang, Liu Ting, Chen Yushan, Wang Xiaohua
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Department of Nursing, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Metabolites. 2022 Oct 13;12(10):969. doi: 10.3390/metabo12100969.
Metabolic abnormalities as side effects of androgen-deprivation therapy (ADT) can accelerate progression of prostate cancer (PCa) and increase risks of cardiovascular diseases. A healthy dietary pattern (DP) plays an important role in regulating glycolipid metabolism, while evidence about DP on ADT-related metabolic abnormalities is still controversial. To explore the effect of DP on metabolic outcomes in PCa patients with ADT, PubMed, Embase, Cochrane, and CINAHL were searched from inception to 10 September 2022. Risk of biases was evaluated through Cochrane Collaboration’s Tool. If heterogeneity was low, the fixed-effects model was carried out; otherwise, the random-effects model was used. Data were determined by calculating mean difference (MD) or standardized MD (SMD) with 95% confidence intervals (CIs). Nine studies involving 421 patients were included. The results showed that healthy DP significantly improved glycated hemoglobin (MD: −0.13; 95% CI: −0.24, −0.02; p = 0.020), body mass index (MD: −1.02; 95% CI: −1.29, −0.75; p < 0.001), body fat mass (MD: −1.78; 95% CI: −2.58, −0.97; p < 0.001), triglyceride (MD: −0.28; 95% CI: −0.51, −0.04; p = 0.020), systolic blood pressure (MD: −6.30; 95% CI: −11.15, −1.44; p = 0.010), and diastolic blood pressure (MD: −2.94; 95% CI: −5.63, −0.25; p = 0.030), although its beneficial effects on other glycolipid metabolic indicators were not found. Additionally, a healthy DP also lowered the level of PSA (MD: −1.79; 95% CI: −2.25, −1.33; p < 0.001). The meta-analysis demonstrated that a healthy DP could improve ADT-related metabolic abnormalities and be worthy of being recommended for PCa patients with ADT.
代谢异常作为雄激素剥夺疗法（ADT）的副作用，可加速前列腺癌（PCa）的进展并增加心血管疾病风险。健康的饮食模式（DP）在调节糖脂代谢中起重要作用，而关于DP对ADT相关代谢异常影响的证据仍存在争议。为探讨DP对接受ADT的PCa患者代谢结局的影响，检索了PubMed、Embase、Cochrane和CINAHL数据库，检索时间从建库至2022年9月10日。通过Cochrane协作工具评估偏倚风险。若异质性较低，则采用固定效应模型；否则，采用随机效应模型。通过计算平均差（MD）或标准化平均差（SMD）及95%置信区间（CI）来确定数据。纳入了9项涉及421例患者的研究。结果显示，健康的DP显著改善了糖化血红蛋白（MD：−0.13；95%CI：−0.24，−0.02；p = 0.020）、体重指数（MD：−1.02；95%CI：−1.29，−0.75；p < 0.001）、体脂肪量（MD：−1.78；95%CI：−2.58，−0.97；p < 0.001）、甘油三酯（MD：−0.28；95%CI：−0.51，−0.04；p = 0.020）、收缩压（MD：−6.30；95%CI：−11.15，−1.44；p = 0.010）和舒张压（MD：−2.94；95%CI：−5.63，−0.25；p = 0.030），尽管未发现其对其他糖脂代谢指标有有益影响。此外，健康的DP还降低了前列腺特异抗原（PSA）水平（MD：−1.79；95%CI：−2.25，−1.33；p < 0.001）。荟萃分析表明，健康的DP可改善ADT相关的代谢异常，值得推荐给接受ADT的PCa患者。
