Department of Applied Microbiology and Human Nutrition Physiology, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology, ul. Papieża Pawła VI 3, 71-459 Szczecin, Poland.
Department of Physiology and Biochemistry, Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland.
Nutrients. 2022 Oct 17;14(20):4350. doi: 10.3390/nu14204350.
Relationships between diet, sex hormone concentrations, and the estrous cycle are important from the perspective of infertility and estrogen-dependent disease prevention and treatment. Four dietary interventions reflecting modern eating behaviors were explored. The study involved 50 female rats divided into five feeding groups. The impact of the amount of sucrose consumed (9% and 18% of the dietary energy content), alternating high-sucrose and sucrose-free diets, and a high-sucrose diet combined with intermittent one-day fasting on the estrous cycle and sex hormone concentrations in female rats was assessed. Even low amounts of dietary sucrose (9% of the dietary energy content) were found to lead to increased estradiol (E2) concentrations and decreased progesterone (Pg) concentrations. A high-sucrose diet, even when periodically applied, additionally led to a reduced concentration of luteinizing hormone (LH). The largest changes in the hormones tested were observed with one-day fasting coupled with the high-sucrose diet; in addition, the estrous phase was shortened and the estrous cycle was disrupted. The results of this study show that both the amount of dietary sucrose and also its uptake pattern affect the estrous cycle and sex hormone concentrations in female rats.
饮食、性激素浓度与发情周期之间的关系对于不孕和雌激素依赖性疾病的预防和治疗非常重要。本研究探索了四种反映现代饮食行为的饮食干预方法。研究涉及 50 只雌性大鼠，分为 5 个饲养组。评估了蔗糖摄入量（占饮食能量的 9%和 18%）、交替高蔗糖和无糖饮食以及高蔗糖饮食与间歇性一天禁食对雌性大鼠发情周期和性激素浓度的影响。即使饮食中含有少量蔗糖（占饮食能量的 9%）也会导致雌二醇（E2）浓度升高和孕酮（Pg）浓度降低。即使周期性应用高蔗糖饮食也会导致促黄体生成激素（LH）浓度降低。在接受高蔗糖饮食的同时进行一天禁食时，观察到测试激素的变化最大；此外，发情期缩短，发情周期紊乱。本研究结果表明，饮食中蔗糖的含量及其摄取方式均会影响雌性大鼠的发情周期和性激素浓度。
