Ding Z Z, Lyu J
National Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Oct 20;38(10):973-977. doi: 10.3760/cma.j.cn501225-20220602-00212.
Silk fibroin, a natural fibrin, is a suitable matrix biomaterial for wound repair due to its unique properties such as good biocompatibility, tunable biodegradation and mechanical properties, low host inflammatory response, low cost, ease of fabrication, etc. Silk fibroin can be used alone or in combination with other materials to construct various dressings including scaffolds, hydrogels, films, smart mats, and microneedles, which can meet the needs of different wound repair and regulate the wound repair process. Thus, the application research of silk fibroin in skin tissue engineering has increased dramatically. Compared with other natural materials, silk fibroin promotes tissue regeneration and wound repair by improving cell proliferation, migration, and differentiation behavior at different stages, showing unique advantages in different dimensions. Based on the development of silk fibroin wound repair materials in the recent years, this review focuses on the mechanism and application prospect of silk fibroin and its composite materials in wound repair.
丝素蛋白是一种天然纤维蛋白，由于其具有良好的生物相容性、可调节的生物降解性和机械性能、低宿主炎症反应、低成本、易于制备等独特性能，是一种适用于伤口修复的基质生物材料。丝素蛋白可单独使用或与其他材料结合使用，以构建包括支架、水凝胶、薄膜、智能垫和微针在内的各种敷料，这些敷料可以满足不同伤口修复的需求并调节伤口修复过程。因此，丝素蛋白在皮肤组织工程中的应用研究急剧增加。与其他天然材料相比，丝素蛋白通过改善不同阶段的细胞增殖、迁移和分化行为来促进组织再生和伤口修复，在不同维度上显示出独特的优势。基于近年来丝素蛋白伤口修复材料的发展，本综述重点关注丝素蛋白及其复合材料在伤口修复中的作用机制和应用前景。
