Down-regulation of , and in gastric cancer.

Long non-coding RNAs (lncRNAs) have been identified as modulators of gastric carcinogenesis. Evaluation of expression amounts of these transcripts is a primary but essential step for recognition of the role of lncRNAs in the carcinogenesis. Therefore, we compared expressions of , , and lncRNAs in gastric cancer samples and nearby non-cancerous samples. Expression levels of , and lncRNAs have been lower in gastric cancer samples compared with nearby non-cancerous samples (Expression ratios = 0.26, 0.37 and 0.36; P values = 0.021, 0.015 and 0.032, respectively). However, expression levels of were not significantly different between gastric cancer tissues and nearby tissues (P value = 0.43). expression was associated with tumor size (P value = 0.04). In addition, expression was associated with site of primary tumor (P = 0.0003). Expressions of and were not associated with any clinical or pathological parameter. ROC curve analysis revealed that and could significantly differentiate between gastric cancer samples and nearby non-cancerous tissues (AUC values = 0.68 and 0.64; P values = 0.01 and 0.04, respectively). Taken together, the current investigation provides clues for contribution of , and lncRNAs in gastric carcinogenesis and warrants further mechanistical assays.