免疫方案中应对抗原变异性的自动化策略，第二部分：针对传染性病原体变异体接种的体外转录 mRNA 载体设计。
An Automated Strategy to Handle Antigenic Variability in Immunisation Protocols, Part II: In Vitro Transcribed mRNA Vector Design for Inoculation Against Infectious Agent Variants.
机构信息
Bioengineering Department, Imperial College London, London, UK.
出版信息
Methods Mol Biol. 2023;2575:323-340. doi: 10.1007/978-1-0716-2716-7_17.
PMID:36301484
Abstract
A fully automated strategy to handle antigenic variability in immunisation protocols is here presented. The method comprises of (1) nanopore sequencing of infectious agent variants, with focus on the SARS-CoV-2 and its variants, followed by (2) in-vitro transcribed mRNA vector design for immunotherapy. This chapter introduces the mRNA vector design protocol and Chapter 16 presents the nano-pore sequencing step.
摘要
现提出一种全自动策略来处理免疫方案中的抗原变异性。该方法包括（1）对传染性病原体变体进行纳米孔测序，重点是 SARS-CoV-2 及其变体，随后进行（2）用于免疫疗法的体外转录 mRNA 载体设计。本章介绍了 mRNA 载体设计方案，第 16 章介绍了纳米孔测序步骤。
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