地中海-得舒饮食延缓神经退行性变（MIND）饮食与乳腺癌风险的关系：一项针对伊朗成年女性的病例对照研究。

The relationship between Mediterranean-DASH diet intervention for the neurodegenerative delay (MIND) Diet and risk of breast Cancer: a case-control study among iranian adult women.

作者信息

Mokhtari Ebrahim, Jamshidi Sanaz, Farhadnejad Hossein, Teymoori Farshad, Rashidkhani Bahram, Mirmiran Parvin, Tehrani Fahimeh Ramezani, Heidari Zeinab

机构信息

Student Research Committee, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, PO Box: 19395-4741, Tehran, Iran.

出版信息

BMC Nutr. 2022 Oct 27;8(1):123. doi: 10.1186/s40795-022-00614-8.

DOI:10.1186/s40795-022-00614-8

PMID:36303232

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9615230/

Abstract

BACKGROUND

choosing a healthier lifestyle and modifying dietary habits could prevent four million new people from developing cancer. Recently, a new index called the Mediterranean-dietary approach to stop hypertension (DASH) diet intervention for the neurodegenerative delay (MIND) diet has been developed. In the current study, we aimed to assess the relationship between the MIND diet and the risk of breast cancer (BC) among Tehranian adult women.

METHOD

In this hospital-based, case-control study, 134 Tehranian women ≥ 30 years old with recently (< 6 months) diagnosed BC, confirmed histologically and 272 women of the same age as control were included. Dietary intakes were assessed in a personal interview using a valid and reliable semi-quantitative 168-item food frequency questionnaire. The odds ratio (OR) and 95% confidence intervals (CI) of breast cancer across tertiles of the MIND diet were determined using multivariable-adjusted logistic regression analysis.

RESULTS

In the crude model, participants in the highest tertiles had lower odds of BC [(OR = 0.57; 95% CI,0.34-0.95), P for trend = 0.020)] than those with the lowest scores on the MIND diet. After controlling for potential confounding variables, individuals in the highest tertile of the MIND diet had a 45% lower risk of BC [(OR = 0.55; 95% CI, 0.32-0.96), P for trend = 0.021)] compared with those in the lowest tertile. Also, in women with an abortion history, higher adherence to the MIND diet was associated with a lower risk of BC [(OR = 0.15; 95% CI, 0.04-0.52, P for trend = 0.002)].

CONCLUSION

Our findings revealed that higher adherence to the MIND diet was associated with decreased BC risk, which was strongly observed among women with a history of abortion.

摘要

背景

选择更健康的生活方式并改变饮食习惯可预防400万人患癌。最近，一种名为地中海饮食法阻止高血压（DASH）饮食干预延缓神经退行性变（MIND）饮食的新指标被开发出来。在本研究中，我们旨在评估德黑兰成年女性中MIND饮食与乳腺癌（BC）风险之间的关系。

方法

在这项基于医院的病例对照研究中，纳入了134名年龄≥30岁、近期（<6个月）经组织学确诊为乳腺癌的德黑兰女性，以及272名年龄相同的对照女性。通过使用有效且可靠的半定量168项食物频率问卷进行个人访谈来评估饮食摄入量。使用多变量调整逻辑回归分析确定MIND饮食三分位数中乳腺癌的比值比（OR）和95%置信区间（CI）。

结果

在粗模型中，与MIND饮食得分最低的参与者相比，最高三分位数的参与者患乳腺癌的几率更低[（OR = 0.57；95% CI，0.34 - 0.95），趋势P值 = 0.020]。在控制潜在混杂变量后，MIND饮食最高三分位数的个体患乳腺癌的风险比最低三分位数的个体低45%[（OR = 0.55；95% CI，0.32 - 0.96），趋势P值 = 0.021]。此外，在有流产史的女性中，更高程度地坚持MIND饮食与更低的乳腺癌风险相关[（OR = 0.15；95% CI，0.04 - 0.52，趋势P值 = 0.002）]。