Yin Yi, Han Xing, Li Cheng, Sun Tonghui, Li Kailin, Liu Xionghao, Liu Mujun
Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Front Pharmacol. 2022 Oct 11;13:961127. doi: 10.3389/fphar.2022.961127. eCollection 2022.
Exosomes, as natural biomolecular carriers produced by cells, have the potential and advantage of delivering drugs to target organs or cells . The steps to improve exosomes as a drug delivery system can be divided into three steps:large-scale preparation of exosomes, loading of drugs and targeted delivery of exosomes. Based on the existing production process and technology, there is still much room for improvement. This review highlights the research progress in three aspects and proposes new technologies and innovative approaches to improve the efficiency of exosome delivery.
外泌体作为细胞产生的天然生物分子载体，具有将药物递送至靶器官或细胞的潜力和优势。将外泌体改进为药物递送系统的步骤可分为三步：外泌体的大规模制备、药物装载以及外泌体的靶向递送。基于现有的生产工艺和技术，仍有很大的改进空间。本综述重点介绍了这三个方面的研究进展，并提出了提高外泌体递送效率的新技术和创新方法。
