Mei Yang, Chen Qi, Li Yu-Ping, Chen Yao-Hua, Xia Juan, Zeng Jie, Yu Le-Hua, Li Wei, Cui Jian
Department of Pain Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Department of Pain Medicine, Southwest Hospital, Army Medical University, Chongqing, China.
Front Mol Neurosci. 2023 Feb 1;16:1128429. doi: 10.3389/fnmol.2023.1128429. eCollection 2023.
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to explore the relationship between genetic polymorphisms of AMPK gene (Rs13361707, rs3792822, and rs10074991) in and postherpetic neuralgia (PHN) in Chinese individuals. Hundred and thirty two patients with PHN and 118 control individuals were enrolled in this study. All blood samples were shuffled and blinded to the person performing the haplotype analysis. Rs13361707, rs3792822, and rs10074991 genotypes were identified in all participants. Dominant and recessive models were used for evaluating the association between these nucleotide polymorphisms and PHN susceptibility. A haplotype analysis of PHN patients and healthy controls was performed. Clinical characteristics between the two groups were not significantly different ( > 0.05) except that the ages in control subjects were younger than the PHN patients ( < 0.05). Genotypes and allele frequencies are significantly different between the PHN patients and control subjects for the rs13361707 and rs10074991 polymorphisms ( < 0.05), but not for rs3792822 ( > 0.05). In addition, the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence, but TCA was positively correlated with PHN ( < 0.05). Our results indicate that gene polymorphisms rs13361707 and rs10074991 were associated with a risk of PHN, and that the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence in haplotype analysis. TCA was positively associated with PHN in Chinese individuals.
5'-单磷酸腺苷（AMP）激活的蛋白激酶（AMPK）是能量代谢中的关键调节蛋白。在一项初步研究中，我们发现神经元中与AMPK相关的能量代谢失衡促成了神经性疼痛（NeP）的发生和维持。本研究旨在探讨中国人群中AMPK基因（Rs13361707、rs3792822和rs10074991）的基因多态性与带状疱疹后神经痛（PHN）之间的关系。本研究纳入了132例PHN患者和118例对照个体。所有血样均进行了随机排列，并对进行单倍型分析的人员进行了盲法处理。在所有参与者中鉴定了Rs13361707、rs3792822和rs10074991的基因型。采用显性和隐性模型评估这些核苷酸多态性与PHN易感性之间的关联。对PHN患者和健康对照进行了单倍型分析。两组之间的临床特征无显著差异（P>0.05），但对照组的年龄比PHN患者年轻（P<0.05）。对于rs13361707和rs10074991多态性，PHN患者和对照个体之间的基因型和等位基因频率存在显著差异（P<0.05），但对于rs3792822则无显著差异（P>0.05）。此外，rs13361707-rs3792822-rs10074991的CCG单倍型与PHN的发生呈负相关，但TCA与PHN呈正相关（P<0.05）。我们的结果表明，AMPK基因多态性rs13361707和rs10074991与PHN风险相关，并且在单倍型分析中rs13361707-rs3792822-rs10074991的CCG单倍型与PHN的发生呈负相关。在中国个体中，TCA与PHN呈正相关。
