Department of Quality Assurance, ISF College of Pharmacy, GT Road, Moga-142001, Punjab, India.
Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga-142001, Punjab, India.
Pharm Nanotechnol. 2023;11(2):138-154. doi: 10.2174/2211738511666221026163303.
Solid lipid nanoparticles are at the cornerstone of the swiftly growing area of medical nanotechnology, having several potential functions in drug delivery, research, clinical care, and a variety of other fields. They provide the opportunity of developing novel therapies due to their unique properties, such as small particle size and being prepared from physiological biodegradable lipids. The loading of bioactive molecules into nanocarriers is a novel drug delivery prototype employed for various drug targeting levels. Hence, SLNs hold a great promise for achieving the aim of targeted and controlled drug delivery. For this reason, they have attracted the extensive attention of scientists and researchers. This review is based on recent studies and research, and here we present advantages, disadvantages, and preparation methods, several advanced modifications, targeting strategies, and recent applications of solid lipid nanocarriers in drug delivery systems.
固体脂质纳米粒是医学纳米技术迅速发展领域的基石，在药物传递、研究、临床护理和其他各种领域具有多种潜在功能。由于其独特的性质，如小颗粒尺寸和由生理可生物降解的脂质制备，它们为开发新型疗法提供了机会。将生物活性分子载入纳米载体是一种新型的药物传递原型，用于各种药物靶向水平。因此，SLN 有望实现靶向和控制药物传递的目标。出于这个原因，它们引起了科学家和研究人员的广泛关注。本综述基于最近的研究，在此我们介绍了固体脂质纳米载体在药物传递系统中的优点、缺点和制备方法、几种先进的修饰、靶向策略和最新应用。
