Mishra Vijay, Bansal Kuldeep K, Verma Asit, Yadav Nishika, Thakur Sourav, Sudhakar Kalvatala, Rosenholm Jessica M
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo Akademi University, 20520 Turku, Finland.
Pharmaceutics. 2018 Oct 18;10(4):191. doi: 10.3390/pharmaceutics10040191.
Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.
固体脂质纳米粒（SLNs）是作为与脂质体、脂质乳剂、聚合物纳米粒等平行的替代胶体药物递送系统而开发的纳米载体。由于其独特的尺寸依赖性性质和包载药物的能力，固体脂质纳米粒为构建新的药物递送和靶向治疗原型提供了机会。固体脂质纳米粒在实现靶向和控释药物递送目标方面具有巨大潜力，目前这吸引了全球研究人员的关注。本综述阐述了固体脂质纳米粒的不同方面，包括制备和表征技术、制剂变量、给药途径、表面修饰、毒性以及生物医学应用。
