饮食质量与多种族队列人群中的胰腺癌发病风险。

Diet Quality and Pancreatic Cancer Incidence in the Multiethnic Cohort.

机构信息

Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, California.

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

出版信息

Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):123-131. doi: 10.1158/1055-9965.EPI-22-0564.

DOI:10.1158/1055-9965.EPI-22-0564

PMID:36306381

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10072126/

Abstract

BACKGROUND

Data on diet quality and pancreatic cancer are limited. We examined the relationship between diet quality, assessed by the Healthy Eating Index-2015 (HEI-2015), the Alternative Healthy Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED) score, the Dietary Approaches to Stop Hypertension (DASH) score and the energy-adjusted Dietary Inflammatory Index (E-DII), and pancreatic cancer incidence in the Multiethnic Cohort Study.

METHODS

Diet quality scores were calculated from a validated food frequency questionnaire administered at baseline. Cox models were used to calculate HR and 95% confidence intervals (CI) adjusted for age, sex, race/ethnicity, education, diabetes, family history of pancreatic cancer, physical activity, smoking variables, total energy intake, body mass index (BMI), and alcohol consumption. Stratified analyses by sex, race/ethnicity, smoking status, and BMI were conducted.

RESULTS

Over an average follow-up of 19.3 years, 1,779 incident pancreatic cancer cases were identified among 177,313 participants (average age of 60.2 years at baseline, 1993-1996). Overall, we did not observe associations between the dietary pattern scores and pancreatic cancer (aMED: 0.98; 95% CI, 0.83-1.16; HEI-2015: 1.03; 95% CI, 0.88-1.21; AHEI-2010: 1.03; 95% CI, 0.88-1.20; DASH: 0.92; 95% CI, 0.79-1.08; E-DII: 1.05; 95% CI, 0.89-1.23). An inverse association was observed with DASH for ever smokers (HR, 0.75; 0.61-0.93), but not for nonsmokers (HR, 1.05; 0.83-1.32).

CONCLUSIONS

The DASH diet showed an inverse association with pancreatic cancer among ever smokers, but does not show a protective association overall.

IMPACT

Modifiable measures are needed to reduce pancreatic cancer burden in these high-risk populations; our study adds to the discussion of the benefit of dietary changes.

摘要

背景

关于饮食质量与胰腺癌之间关系的数据有限。我们研究了通过健康饮食指数-2015（HEI-2015）、替代健康饮食指数-2010（AHEI-2010）、替代地中海饮食（aMED）评分、停止高血压的饮食方法（DASH）评分和能量调整饮食炎症指数（E-DII）评估的饮食质量与胰腺癌发病风险之间的关系，这项研究是在多民族队列研究中进行的。

方法

饮食质量评分是根据基线时的一份经过验证的食物频率问卷计算得出的。Cox 模型用于计算经年龄、性别、种族/民族、教育程度、糖尿病、胰腺癌家族史、身体活动、吸烟变量、总能量摄入、体重指数（BMI）和酒精摄入量调整后的 HR 和 95%置信区间（CI）。按性别、种族/民族、吸烟状况和 BMI 进行分层分析。

结果

在平均 19.3 年的随访中，在 177313 名参与者中发现了 1777 例胰腺癌病例（基线时的平均年龄为 60.2 岁，1993-1996 年）。总体而言，我们没有观察到饮食模式评分与胰腺癌之间存在关联（aMED：0.98；95%CI，0.83-1.16；HEI-2015：1.03；95%CI，0.88-1.21；AHEI-2010：1.03；95%CI，0.88-1.20；DASH：0.92；95%CI，0.79-1.08；E-DII：1.05；95%CI，0.89-1.23）。DASH 饮食对于曾经吸烟者与胰腺癌呈负相关（HR，0.75；0.61-0.93），而非吸烟者则无此关联（HR，1.05；0.83-1.32）。