Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
The Royal Marsden Hospitals NHS Trust, London, UK.
Br J Cancer. 2023 Feb;128(3):404-406. doi: 10.1038/s41416-022-02009-9. Epub 2022 Oct 28.
The Armitage Doll model demonstrates that the impact of age-dependent exposure to carcinogenic factors depends on whether the induced change occurs early, at the midpoint or late in carcinogenesis. 70 years on, updated modelling shows that their epidemiological observations still provide insight into clinical observations and their underlying molecular mechanisms.
阿密特奇玩偶模型表明，与致癌因素相关的年龄暴露的影响取决于诱导性变化发生在癌变的早期、中期还是晚期。70 年后，更新的模型表明，他们的流行病学观察结果仍然为临床观察及其潜在的分子机制提供了深入了解。
