非酒精性脂肪性肝病在年轻患者而非老年患者中与重症 COVID-19 独立相关：一项荟萃分析。 - Suppr

Suppr

超能文献

NAFLD was independently associated with severe COVID-19 among younger patients rather than older patients: A meta-analysis.

作者信息

Wang Ying, Wang Yadong, Duan Guangcai, Yang Haiyan

机构信息

Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.

出版信息

J Hepatol. 2023 Apr;78(4):e136-e139. doi: 10.1016/j.jhep.2022.10.009. Epub 2022 Oct 26.

DOI:10.1016/j.jhep.2022.10.009

PMID:36309129

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9597581/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdb/9597581/1960b202d61f/gr1_lrg.jpg

相似文献

NAFLD was independently associated with severe COVID-19 among younger patients rather than older patients: A meta-analysis.非酒精性脂肪性肝病在年轻患者而非老年患者中与重症 COVID-19 独立相关：一项荟萃分析。

J Hepatol. 2023 Apr;78(4):e136-e139. doi: 10.1016/j.jhep.2022.10.009. Epub 2022 Oct 26.

Association of Cardiovascular Risk Factors and Metabolic Syndrome with non-alcoholic and alcoholic fatty liver disease: a retrospective analysis.心血管危险因素和代谢综合征与非酒精性和酒精性脂肪性肝病的关系：一项回顾性分析。

BMC Endocr Disord. 2021 May 1;21(1):91. doi: 10.1186/s12902-021-00758-x.

Letter to the Editor: Obesity, diabetes, non-alcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease are proinflammatory hypercoagulable states associated with severe disease and thrombosis in Covid-19.致编辑的信：肥胖、糖尿病、非酒精性脂肪性肝病和代谢功能障碍相关脂肪性肝病是与新冠病毒疾病严重程度及血栓形成相关的促炎高凝状态。

Metabolism. 2021 Feb;115:154437. doi: 10.1016/j.metabol.2020.154437. Epub 2020 Nov 19.

Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome and cardiovascular events in atrial fibrillation. A prospective multicenter cohort study.非酒精性脂肪性肝病（NAFLD）、代谢综合征与心房颤动中的心血管事件。一项前瞻性多中心队列研究。

Intern Emerg Med. 2021 Nov;16(8):2063-2068. doi: 10.1007/s11739-021-02682-3. Epub 2021 Mar 13.

Metabolic syndrome, non-alcoholic fatty liver disease and liver stiffness in psoriatic arthritis and psoriasis patients.代谢综合征、非酒精性脂肪性肝病与银屑病关节炎及银屑病患者的肝硬度。

Clin Rheumatol. 2019 Oct;38(10):2843-2850. doi: 10.1007/s10067-019-04646-7. Epub 2019 Jun 28.

Impact of Fibrosis-4 Index Prior to COVID-19 on Outcomes in Patients at Risk of Non-alcoholic Fatty Liver Disease.新冠肺炎疫情前 Fibrosis-4 指数对非酒精性脂肪性肝病高危患者结局的影响。

Dig Dis Sci. 2022 Jul;67(7):3333-3339. doi: 10.1007/s10620-021-07120-0. Epub 2021 Jun 26.

Association of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome Independently of Central Obesity and Insulin Resistance.非酒精性脂肪性肝病与代谢综合征的关联独立于中心性肥胖和胰岛素抵抗。

Sci Rep. 2016 Jun 1;6:27034. doi: 10.1038/srep27034.

Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk.非酒精性脂肪性肝病、胰岛素抵抗、代谢综合征及其与血管风险的关系。

Metabolism. 2021 Jun;119:154770. doi: 10.1016/j.metabol.2021.154770. Epub 2021 Apr 14.

Clinical Characteristics and Metabolic Profiles of Non-Alcoholic Fatty Liver Disease (NAFLD) in Lean Patients and Their Comparison with Obese and Overweight NAFLD.瘦型非酒精性脂肪性肝病（NAFLD）患者的临床特征和代谢特征及其与肥胖和超重 NAFLD 的比较。

J Assoc Physicians India. 2022 Apr;70(4):11-12.

Non-alcoholic fatty liver disease and clinical outcomes in patients with COVID-19: A comprehensive systematic review and meta-analysis.非酒精性脂肪性肝病与 COVID-19 患者临床结局的关系：一项全面的系统综述和荟萃分析。

Diabetes Metab Syndr. 2021 May-Jun;15(3):813-822. doi: 10.1016/j.dsx.2021.03.019. Epub 2021 Mar 31.

引用本文的文献

Risk of Serious Bacterial and Non-Bacterial Infections in People With MASLD.患有代谢功能障碍相关脂肪性肝病（MASLD）的人群发生严重细菌和非细菌感染的风险

Liver Int. 2025 Apr;45(4):e70059. doi: 10.1111/liv.70059.

Association between MASLD and increased risk of serious bacterial infections requiring hospital admission: A meta-analysis.非酒精性脂肪性肝炎与需要住院治疗的严重细菌感染风险增加之间的关联：一项荟萃分析。

Liver Int. 2025 Apr;45(4):e16101. doi: 10.1111/liv.16101. Epub 2024 Sep 11.

Exploring Paxlovid Efficacy in COVID-19 Patients with MAFLD: Insights from a Single-Center Prospective Cohort Study.探讨 MAFLD 患者应用 Paxlovid 的疗效：一项单中心前瞻性队列研究的启示。

Viruses. 2024 Jan 12;16(1):112. doi: 10.3390/v16010112.

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis.遗传因素预测 COVID-19 和 MAFLD 共病病程：综合分析。

Viruses. 2023 Aug 12;15(8):1724. doi: 10.3390/v15081724.

A Meta-Analysis on the Association between Peptic Ulcer Disease and COVID-19 Severity.消化性溃疡疾病与新型冠状病毒肺炎严重程度关联的Meta分析

Vaccines (Basel). 2023 Jun 11;11(6):1087. doi: 10.3390/vaccines11061087.

The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence.新型冠状病毒肺炎与代谢相关脂肪性肝病的关系：当前证据概述。

Viruses. 2023 Apr 27;15(5):1072. doi: 10.3390/v15051072.

More efforts to explore the association between cirrhosis and COVID-19 mortality, and the association between NAFLD and severe COVID-19.加大力度探索肝硬化与新冠肺炎死亡率之间的关联，以及非酒精性脂肪性肝病与重症新冠肺炎之间的关联。

J Hepatol. 2023 May;78(5):e178-e180. doi: 10.1016/j.jhep.2022.11.024. Epub 2022 Dec 9.

本文引用的文献

Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper.COVID-19 对肝脏的影响以及对慢性肝病、肝胆癌和肝移植患者的治疗影响：EASL 最新立场文件。

J Hepatol. 2022 Oct;77(4):1161-1197. doi: 10.1016/j.jhep.2022.07.008. Epub 2022 Jul 20.

Protected or not protected, that is the question - First data on COVID-19 vaccine responses in patients with NAFLD and liver transplant recipients.是否受到保护，这就是问题所在——关于非酒精性脂肪性肝病患者和肝移植受者对新冠病毒疫苗反应的首批数据。

J Hepatol. 2021 Aug;75(2):265-266. doi: 10.1016/j.jhep.2021.05.007. Epub 2021 May 25.

EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients.EASL 立场文件：关于在慢性肝病、肝胆癌和肝移植受者中使用 COVID-19 疫苗的建议。

J Hepatol. 2021 Apr;74(4):944-951. doi: 10.1016/j.jhep.2021.01.032. Epub 2021 Feb 6.

SARS-CoV-2 infection in patients with autoimmune hepatitis.严重急性呼吸综合征冠状病毒 2 感染自身免疫性肝炎患者。

J Hepatol. 2021 Jun;74(6):1335-1343. doi: 10.1016/j.jhep.2021.01.021. Epub 2021 Jan 26.

NAFLD is a predictor of liver injury in COVID-19 hospitalized patients but not of mortality, disease severity on the presentation or progression - The debate continues.非酒精性脂肪性肝病是新冠病毒肺炎住院患者肝损伤的一个预测指标，但不是死亡率、就诊时疾病严重程度或病情进展的预测指标——争论仍在继续。

J Hepatol. 2021 Feb;74(2):482-484. doi: 10.1016/j.jhep.2020.09.006. Epub 2020 Nov 19.

Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study.新型冠状病毒肺炎患者的非酒精性脂肪性肝病：一项回顾性研究。

J Hepatol. 2020 Aug;73(2):451-453. doi: 10.1016/j.jhep.2020.03.044. Epub 2020 Apr 8.

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.评估卫生保健干预措施的研究的系统评价和Meta分析报告的PRISMA声明：解释与详述。

PLoS Med. 2009 Jul 21;6(7):e1000100. doi: 10.1371/journal.pmed.1000100.

Bias in meta-analysis detected by a simple, graphical test.通过一种简单的图形检验检测荟萃分析中的偏倚。

BMJ. 1997 Sep 13;315(7109):629-34. doi: 10.1136/bmj.315.7109.629.

Operating characteristics of a rank correlation test for publication bias.用于发表偏倚的秩相关检验的操作特征

Biometrics. 1994 Dec;50(4):1088-101.

Quantitative methods in the review of epidemiologic literature.流行病学文献综述中的定量方法。

Epidemiol Rev. 1987;9:1-30. doi: 10.1093/oxfordjournals.epirev.a036298.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验