Department of Wood and Paper Science and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland; Health Research Institute and AMBER, University of Limerick, Limerick V94 T9PX, Ireland.
Int J Biol Macromol. 2023 Jan 1;224:1196-1205. doi: 10.1016/j.ijbiomac.2022.10.205. Epub 2022 Oct 26.
In this study, hydrogels based on gelatin and lignin were fabricated as efficient drug carriers for Ribavirin. The obtained hydrogels were characterized by scanning electron microscopy (SEM), ATR-FTIR spectroscopy, differential scanning calorimetry (DSC), mechanical compression and rheometry. Results showed that the pore structure, viscoelastic behavior and swelling ability significantly influenced by varying lignin content and crosslinker ratio. By increasing the crosslinker N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) content, the pore size became smaller, while increasing the lignin content resulted in larger pores. In addition, all hydrogels show strong shear thinning behavior. Ribavirin was used as a drug model, and its release rate was enhanced by increasing lignin content in the binary hydrogel structure. A higher Ribavirin cumulative release was observed for gelatin/lignin with higher lignin content (3 %) hydrogel. These findings emphasize the chemical composition on the structure and the release behavior of lignin-containing hydrogels.
在这项研究中，制备了基于明胶和木质素的水凝胶，作为利巴韦林的有效药物载体。通过扫描电子显微镜（SEM）、衰减全反射傅里叶变换红外光谱（ATR-FTIR）、差示扫描量热法（DSC）、机械压缩和流变学对获得的水凝胶进行了表征。结果表明，木质素含量和交联剂比对孔结构、粘弹性行为和溶胀能力有显著影响。通过增加交联剂 N-(3-二甲基氨基丙基)-N'-乙基碳二亚胺盐酸盐（EDC）的含量，孔径变小，而增加木质素含量则导致孔径变大。此外，所有水凝胶均表现出较强的剪切稀化行为。利巴韦林被用作药物模型，通过增加二元水凝胶结构中的木质素含量来提高其释放速率。具有更高木质素含量（3%）的明胶/木质素水凝胶观察到更高的利巴韦林累积释放率。这些发现强调了木质素含量对水凝胶结构和释放行为的化学组成的影响。
